Abstract
Experimentally-based models of the heart have been developed since
1960, starting with the discovery and modelling of potassium channels.
The early models were based on extensions of the Hodgkin-Huxley nerve
impulse equations. The first models including calcium balance and
signalling were made in the 1980s and have now reached a high degree
of physiological detail. During the 1990s these cell models have
been incorporated into anatomically-detailed tissue and organ models
to create the first virtual organ, the Virtual Heart. With over 40
years of interaction between simulation and experiment, the models
are now sufficiently refined to be of use in drug development.
Description
The whole bibliography file I use.