We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.
Description
see page 79 of notebook 00002. This is just a case report of pneumonitis in someone with probable BOS before onset of EBV disease.
Institute of Virology and Antiviral Therapy, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Andi.Krumbholz@med.uni-jena.de
%0 Journal Article
%1 Krumbholz2010
%A Krumbholz, Andi
%A Sandhaus, Tim
%A Göhlert, Angela
%A Heim, Albert
%A Zell, Roland
%A Egerer, Renate
%A Breuer, Martin
%A Straube, Eberhard
%A Wutzler, Peter
%A Sauerbrei, Andreas
%D 2010
%J Med Microbiol Immunol
%K transplantation rejection ebv pneumonia
%N 4
%P 317--322
%R 10.1007/s00430-010-0165-y
%T Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient.
%U http://dx.doi.org/10.1007/s00430-010-0165-y
%V 199
%X We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.
@article{Krumbholz2010,
abstract = {We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.},
added-at = {2012-12-20T23:13:42.000+0100},
author = {Krumbholz, Andi and Sandhaus, Tim and Göhlert, Angela and Heim, Albert and Zell, Roland and Egerer, Renate and Breuer, Martin and Straube, Eberhard and Wutzler, Peter and Sauerbrei, Andreas},
biburl = {https://www.bibsonomy.org/bibtex/264bc253609e19ec9670f96e9fa71778a/aorchid},
description = {see page 79 of notebook 00002. This is just a case report of pneumonitis in someone with probable BOS before onset of EBV disease.},
doi = {10.1007/s00430-010-0165-y},
file = {:allorejection/MedMicrobiolImmunol.199.317.pdf:PDF},
groups = {public},
institution = {Institute of Virology and Antiviral Therapy, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Andi.Krumbholz@med.uni-jena.de},
interhash = {9e979bacc8764dafd5172c7fe44770c5},
intrahash = {64bc253609e19ec9670f96e9fa71778a},
journal = {Med Microbiol Immunol},
keywords = {transplantation rejection ebv pneumonia},
language = {eng},
medline-pst = {ppublish},
month = Nov,
number = 4,
pages = {317--322},
pmid = {20644957},
timestamp = {2012-12-21T00:21:35.000+0100},
title = {Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient.},
url = {http://dx.doi.org/10.1007/s00430-010-0165-y},
username = {aorchid},
volume = 199,
year = 2010
}