%0 Journal Article %1 Yeo1997 %A Yeo, C. L. %A Choo, S. %A Ho, L. Y. %D 1997 %J J Paediatr Child Health %K Cerebral Palsy; Chi-Square Distribution; Chronic Disease; Confidence Intervals; Developmental Disabilities; Humans; Infant, Newborn; Very Low Birth Weight; Logistic Models; Lung Diseases; Odds Ratio; Retrospective Studies; Risk Factors; Severity of Illness Index; Singapore; Survivors; Treatment Outcome %N 2 %P 102--106 %T Chronic lung disease in very low birthweight infants: a 5-year review. %V 33 %X OBJECTIVES: To determine the incidence, clinical spectrum and outcome of very low birthweight (VLBW) infants with chronic lung disease (CLD), and evaluate associated factors. METHODOLOGY: Retrospective review of 265 VLBW infants managed in the NICU from January 1988 to December 1992. RESULTS: The overall neonatal survival rate for VLBW infants was 83\%. Sixty-five (25\%) infants had CLD, of whom 42\% had severe CLD. Mortality in infants with CLD was 11\%. In contrast with infants without CLD, CLD infants had significantly higher risk of adverse neurodevelopment with cerebral palsy documented in 13.5\% and functional disability recorded in 34.6\% at 2 years corrected age. Factors associated with the development of CLD included; decreasing birthweight (OR 0.98, CI 0.97-0.99), septicaemia (OR 4.96, CI 1.57-15.65), necrotizing enterocolitis (OR 119.07, CI 4.98-2845.04), hyaline membrane disease (OR 5.34, CI 1.83-15.55), patent ductus arteriosus (OR 4.46, CI 1.75-11.36) and increasing fraction of inspired oxygen concentration in the first week of life (OR 1.09, CI 1.04-1.14). CONCLUSIONS: Chronic lung disease occurs frequently in VLBW infants and is associated with a high incidence of adverse neurodevelopment. Further studies to clarify the role of non-respiratory factors such as patent ductus arteriosus (PDA) and sepsis in the pathogenesis of CLD may reduce the incidence or prevent the development of CLD in these preterm infants.

@article{Yeo1997, abstract = {OBJECTIVES: To determine the incidence, clinical spectrum and outcome of very low birthweight (VLBW) infants with chronic lung disease (CLD), and evaluate associated factors. METHODOLOGY: Retrospective review of 265 VLBW infants managed in the NICU from January 1988 to December 1992. RESULTS: The overall neonatal survival rate for VLBW infants was 83\%. Sixty-five (25\%) infants had CLD, of whom 42\% had severe CLD. Mortality in infants with CLD was 11\%. In contrast with infants without CLD, CLD infants had significantly higher risk of adverse neurodevelopment with cerebral palsy documented in 13.5\% and functional disability recorded in 34.6\% at 2 years corrected age. Factors associated with the development of CLD included; decreasing birthweight (OR 0.98, CI 0.97-0.99), septicaemia (OR 4.96, CI 1.57-15.65), necrotizing enterocolitis (OR 119.07, CI 4.98-2845.04), hyaline membrane disease (OR 5.34, CI 1.83-15.55), patent ductus arteriosus (OR 4.46, CI 1.75-11.36) and increasing fraction of inspired oxygen concentration in the first week of life (OR 1.09, CI 1.04-1.14). CONCLUSIONS: Chronic lung disease occurs frequently in VLBW infants and is associated with a high incidence of adverse neurodevelopment. Further studies to clarify the role of non-respiratory factors such as patent ductus arteriosus (PDA) and sepsis in the pathogenesis of CLD may reduce the incidence or prevent the development of CLD in these preterm infants.}, added-at = {2014-07-20T09:30:01.000+0200}, author = {Yeo, C. L. and Choo, S. and Ho, L. Y.}, biburl = {https://www.bibsonomy.org/bibtex/2655eebda365add27e24fdaffb95dd4d5/ar0berts}, groups = {public}, interhash = {409276d893ab367389037ec261652f03}, intrahash = {655eebda365add27e24fdaffb95dd4d5}, journal = {J Paediatr Child Health}, keywords = {Cerebral Palsy; Chi-Square Distribution; Chronic Disease; Confidence Intervals; Developmental Disabilities; Humans; Infant, Newborn; Very Low Birth Weight; Logistic Models; Lung Diseases; Odds Ratio; Retrospective Studies; Risk Factors; Severity of Illness Index; Singapore; Survivors; Treatment Outcome}, month = Apr, number = 2, pages = {102--106}, pmid = {9145350}, timestamp = {2014-07-20T09:30:01.000+0200}, title = {Chronic lung disease in very low birthweight infants: a 5-year review.}, username = {ar0berts}, volume = 33, year = 1997 }