%0 Journal Article %1 Kirby200469 %A Kirby, Brian P %A Ryder, Sheila A %A Seiler, Nikolaus %A Renault, Jacques %A Shaw, Graham G %D 2004 %J Brain Research %K Excitatory Intracerebroventricular N-Methyl-D-aspartate N1-dansyl-spermine Neurotransmitters Spermine convulsion excitotoxicity myown %N 1 %P 69 - 73 %R 10.1016/j.brainres.2004.02.075 %T N1-Dansyl-spermine: a potent polyamine antagonist %U http://www.tara.tcd.ie/bitstream/2262/66667/1/Kirby_Ryder_Seiler_Renault_Shaw_2004_N1-dansyl-spermine_a_potent_polyamine_antagonist.pdf %V 1011 %X The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2–10 μg, i.c.v.) with spermine (100 μg, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic convulsions). In addition, the same dose of N1-dansyl-spermine antagonised spermine's enhancement of NMDA-induced convulsions. These results suggest that N1-dansyl-spermine is in vivo a potent antagonist of the CNS effects of spermine and of its action at the positive polyamine modulatory site on the NMDA receptor.

@article{Kirby200469, abstract = {The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2–10 μg, i.c.v.) with spermine (100 μg, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic convulsions). In addition, the same dose of N1-dansyl-spermine antagonised spermine's enhancement of NMDA-induced convulsions. These results suggest that N1-dansyl-spermine is in vivo a potent antagonist of the CNS effects of spermine and of its action at the positive polyamine modulatory site on the NMDA receptor. }, added-at = {2013-07-30T21:57:19.000+0200}, author = {Kirby, Brian P and Ryder, Sheila A and Seiler, Nikolaus and Renault, Jacques and Shaw, Graham G}, biburl = {https://www.bibsonomy.org/bibtex/2677293dd59ccf0c24fcba908a83e3016/sryder}, doi = {10.1016/j.brainres.2004.02.075}, interhash = {a6d96250680397e4b4c4799ef77e788f}, intrahash = {677293dd59ccf0c24fcba908a83e3016}, issn = {0006-8993}, journal = {Brain Research }, keywords = {Excitatory Intracerebroventricular N-Methyl-D-aspartate N1-dansyl-spermine Neurotransmitters Spermine convulsion excitotoxicity myown}, number = 1, pages = {69 - 73}, timestamp = {2013-07-30T22:57:44.000+0200}, title = {N1-Dansyl-spermine: a potent polyamine antagonist }, url = {http://www.tara.tcd.ie/bitstream/2262/66667/1/Kirby_Ryder_Seiler_Renault_Shaw_2004_N1-dansyl-spermine_a_potent_polyamine_antagonist.pdf}, volume = 1011, year = 2004 }