Our objective was to study the effect of hydroalcoholic extract of M. oleifera seeds on high blood pressure in Wistar rat. After 21 days of a high sodium diet, the value of systolic blood pressure and diastolic blood pressure increased from 87. 2 ± 1.96 / 58 ± 0.89 mm to 200.8 ± 0.49 /151.2 ± 1.2 mm Hg (p < 0.05). Administered orally, the extract reduces the high blood pressure of hypertensive rats. It returns to its normal value after 19 days for the control batch, versus 9, 6, and 3 days for the animals treated with the extract at doses 100, 200, and 400 mg/kg (P < 0.05). The extract also has a diuretic activity; the 24 h urinary volume increases from 4.8 ± 0.14 ml in control group, versus 6.85 ± 0.1, 8.3 ± 0.13 and 10.7 ± 0.5 ml in groups treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05), while natriuresis increases from 2.06 ± 0.05 mEq/L in control group, versus 2.92 ± 0.05; 6.82 ± 0.11 and 10.73 ± 0.17 mEq/L in animals treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05). In vitro, it relaxes the isolated aorta contracted with norepinephrine at the concentration of 10-5 M in the bath, with EC50 equal to 2.06 mg/ml (p < 0.05). These results show that the hydroalcoholic extract of M. oleifera seeds has antihypertensive activity through its diuretic and vasodilator effects.
%0 Journal Article
%1 donne_yodan_ralahiravo_2023_8027095
%A RALAHIRAVO, Donné Yodan
%A RAKOTOARISON, Olivier
%A RANDIMBIVOLOLONA, Fanantenanirainy
%A QUANSAH, Nat
%A RANDRIANAVONY, Patricia
%D 2023
%J World Journal of Biology Pharmacy and Health Sciences
%K Moringa oleifera
%N 2
%P 350–356
%R 10.30574/wjbphs.2023.13.2.0110
%T Antihypertensive activity of Moringa oleifera seeds hydroalcoholic extract on high sodium diet-induced hypertension in Wistar Rat
%U https://wjbphs.com/content/antihypertensive-activity-moringa-oleifera-seeds-hydroalcoholic-extract-high-sodium-diet
%V 13
%X Our objective was to study the effect of hydroalcoholic extract of M. oleifera seeds on high blood pressure in Wistar rat. After 21 days of a high sodium diet, the value of systolic blood pressure and diastolic blood pressure increased from 87. 2 ± 1.96 / 58 ± 0.89 mm to 200.8 ± 0.49 /151.2 ± 1.2 mm Hg (p < 0.05). Administered orally, the extract reduces the high blood pressure of hypertensive rats. It returns to its normal value after 19 days for the control batch, versus 9, 6, and 3 days for the animals treated with the extract at doses 100, 200, and 400 mg/kg (P < 0.05). The extract also has a diuretic activity; the 24 h urinary volume increases from 4.8 ± 0.14 ml in control group, versus 6.85 ± 0.1, 8.3 ± 0.13 and 10.7 ± 0.5 ml in groups treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05), while natriuresis increases from 2.06 ± 0.05 mEq/L in control group, versus 2.92 ± 0.05; 6.82 ± 0.11 and 10.73 ± 0.17 mEq/L in animals treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05). In vitro, it relaxes the isolated aorta contracted with norepinephrine at the concentration of 10-5 M in the bath, with EC50 equal to 2.06 mg/ml (p < 0.05). These results show that the hydroalcoholic extract of M. oleifera seeds has antihypertensive activity through its diuretic and vasodilator effects.
@article{donne_yodan_ralahiravo_2023_8027095,
abstract = {Our objective was to study the effect of hydroalcoholic extract of M. oleifera seeds on high blood pressure in Wistar rat. After 21 days of a high sodium diet, the value of systolic blood pressure and diastolic blood pressure increased from 87. 2 ± 1.96 / 58 ± 0.89 mm to 200.8 ± 0.49 /151.2 ± 1.2 mm Hg (p < 0.05). Administered orally, the extract reduces the high blood pressure of hypertensive rats. It returns to its normal value after 19 days for the control batch, versus 9, 6, and 3 days for the animals treated with the extract at doses 100, 200, and 400 mg/kg (P < 0.05). The extract also has a diuretic activity; the 24 h urinary volume increases from 4.8 ± 0.14 ml in control group, versus 6.85 ± 0.1, 8.3 ± 0.13 and 10.7 ± 0.5 ml in groups treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05), while natriuresis increases from 2.06 ± 0.05 mEq/L in control group, versus 2.92 ± 0.05; 6.82 ± 0.11 and 10.73 ± 0.17 mEq/L in animals treated with the extract at doses 100, 200 and 400 mg/kg (p < 0.05). In vitro, it relaxes the isolated aorta contracted with norepinephrine at the concentration of 10-5 M in the bath, with EC50 equal to 2.06 mg/ml (p < 0.05). These results show that the hydroalcoholic extract of M. oleifera seeds has antihypertensive activity through its diuretic and vasodilator effects.},
added-at = {2023-07-17T14:26:32.000+0200},
author = {RALAHIRAVO, Donné Yodan and RAKOTOARISON, Olivier and RANDIMBIVOLOLONA, Fanantenanirainy and QUANSAH, Nat and RANDRIANAVONY, Patricia},
biburl = {https://www.bibsonomy.org/bibtex/26bcfbb19a837997f41af77b75b3c465b/wjbphsjournal},
doi = {10.30574/wjbphs.2023.13.2.0110},
interhash = {20b5cdf19c389dbb55407ff3a2744805},
intrahash = {6bcfbb19a837997f41af77b75b3c465b},
issn = {2582-5542},
journal = {{World Journal of Biology Pharmacy and Health Sciences}},
keywords = {Moringa oleifera},
month = feb,
number = 2,
pages = {350–356},
timestamp = {2023-07-17T14:26:32.000+0200},
title = {Antihypertensive activity of Moringa oleifera seeds hydroalcoholic extract on high sodium diet-induced hypertension in Wistar Rat},
url = {https://wjbphs.com/content/antihypertensive-activity-moringa-oleifera-seeds-hydroalcoholic-extract-high-sodium-diet},
volume = 13,
year = 2023
}