Severe mental retardation (developmental quotient (DQ) < 50) was investigated in 1303 children from 2 to 24 months of age, born during 1984-87 in four population groups representing different socio-economic levels in and around Lahore, Pakistan. The incidence per 1000 live births was 22 in the periurban slum, 9 in the urban slum, 7 in the village and 4 in the upper middle class group. The aetiology was prenatal in 79\%, perinatal in 14\% and untraceable in 7\% of cases. Down's syndrome was the most common cause of severe mental retardation (36\%). Impairments were studied at 2 years of age. Impairment of language was present in all, while locomotor dysfunction was seen in 89\% of cases. Epilepsy and cerebral palsy were each present in 22\% of cases. Mortality among these severely mentally retarded children was 36\%.
%0 Journal Article
%1 Yaqoob1995
%A Yaqoob, M.
%A Bashir, A.
%A Tareen, K.
%A Gustavson, K. H.
%A Nazir, R.
%A Jalil, F.
%A von D?beln, U.
%A Ferngren, H.
%D 1995
%J Acta Paediatr
%K Asphyxia Neonatorum; Cerebral Palsy; Chromosome Aberrations; Disorders; Cohort Studies; Down Syndrome; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Maternal Age; Mental Retardation; Pakistan; Poverty Areas; Social Class
%N 3
%P 267--272
%T Severe mental retardation in 2 to 24-month-old children in Lahore, Pakistan: a prospective cohort study.
%V 84
%X Severe mental retardation (developmental quotient (DQ) < 50) was investigated in 1303 children from 2 to 24 months of age, born during 1984-87 in four population groups representing different socio-economic levels in and around Lahore, Pakistan. The incidence per 1000 live births was 22 in the periurban slum, 9 in the urban slum, 7 in the village and 4 in the upper middle class group. The aetiology was prenatal in 79\%, perinatal in 14\% and untraceable in 7\% of cases. Down's syndrome was the most common cause of severe mental retardation (36\%). Impairments were studied at 2 years of age. Impairment of language was present in all, while locomotor dysfunction was seen in 89\% of cases. Epilepsy and cerebral palsy were each present in 22\% of cases. Mortality among these severely mentally retarded children was 36\%.
@article{Yaqoob1995,
abstract = {Severe mental retardation (developmental quotient (DQ) < 50) was investigated in 1303 children from 2 to 24 months of age, born during 1984-87 in four population groups representing different socio-economic levels in and around Lahore, Pakistan. The incidence per 1000 live births was 22 in the periurban slum, 9 in the urban slum, 7 in the village and 4 in the upper middle class group. The aetiology was prenatal in 79\%, perinatal in 14\% and untraceable in 7\% of cases. Down's syndrome was the most common cause of severe mental retardation (36\%). Impairments were studied at 2 years of age. Impairment of language was present in all, while locomotor dysfunction was seen in 89\% of cases. Epilepsy and cerebral palsy were each present in 22\% of cases. Mortality among these severely mentally retarded children was 36\%.},
added-at = {2014-07-20T09:29:56.000+0200},
author = {Yaqoob, M. and Bashir, A. and Tareen, K. and Gustavson, K. H. and Nazir, R. and Jalil, F. and von D?beln, U. and Ferngren, H.},
biburl = {https://www.bibsonomy.org/bibtex/26da01740a281e77e47d082142a95feb7/ar0berts},
groups = {public},
interhash = {fe3492cf23c4c6dd973dc670c1b5cdf1},
intrahash = {6da01740a281e77e47d082142a95feb7},
journal = {Acta Paediatr},
keywords = {Asphyxia Neonatorum; Cerebral Palsy; Chromosome Aberrations; Disorders; Cohort Studies; Down Syndrome; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Maternal Age; Mental Retardation; Pakistan; Poverty Areas; Social Class},
month = Mar,
number = 3,
pages = {267--272},
pmid = {7780247},
timestamp = {2014-07-20T09:29:56.000+0200},
title = {Severe mental retardation in 2 to 24-month-old children in Lahore, Pakistan: a prospective cohort study.},
username = {ar0berts},
volume = 84,
year = 1995
}