Changes in behavioral state modify neural activity in many
systems 1–5. In some vertebrates such modulation
has been observed and interpreted in the context of attention
2 and sensorimotor coordinate transformations 3. Here we
report state-dependent activity modulations during walking in
a visual-motor pathway of Drosophila. We used two-photon
imaging to monitor intracellular calcium activity in
motion-sensitive lobula plate tangential cells (LPTCs) in
head-fixed Drosophila walking on an air-supported ball. Cells
of the horizontal system (HS)—a subgroup of
LPTCs—showed stronger calcium transients in
response to visual motion when flies were walking rather than
resting. The amplified responses were also correlated with
walking speed. Moreover, HS neurons showed a relatively
higher gain in response strength at higher temporal
frequencies, and their optimum temporal frequency was shifted
toward higher motion speeds. Walking-dependent modulation of
HS neurons in the Drosophila visual system may constitute a
mechanism to facilitate processing of higher image speeds in
behavioral contexts where these speeds of visual motion are
relevant for course stabilization.
%0 Journal Article
%1 chiappe_walking_2010
%A Chiappe, M. Eugenia
%A Seelig, Johannes D.
%A Reiser, Michael B.
%A Jayaraman, Vivek
%D 2010
%J Current Biology
%K drosophila vision
%N 16
%P 1470--1475
%R 10.1016/j.cub.2010.06.072
%T Walking Modulates Speed Sensitivity in Drosophila Motion Vision
%U http://www.sciencedirect.com/science/article/pii/S0960982210008614
%V 20
%X Changes in behavioral state modify neural activity in many
systems 1–5. In some vertebrates such modulation
has been observed and interpreted in the context of attention
2 and sensorimotor coordinate transformations 3. Here we
report state-dependent activity modulations during walking in
a visual-motor pathway of Drosophila. We used two-photon
imaging to monitor intracellular calcium activity in
motion-sensitive lobula plate tangential cells (LPTCs) in
head-fixed Drosophila walking on an air-supported ball. Cells
of the horizontal system (HS)—a subgroup of
LPTCs—showed stronger calcium transients in
response to visual motion when flies were walking rather than
resting. The amplified responses were also correlated with
walking speed. Moreover, HS neurons showed a relatively
higher gain in response strength at higher temporal
frequencies, and their optimum temporal frequency was shifted
toward higher motion speeds. Walking-dependent modulation of
HS neurons in the Drosophila visual system may constitute a
mechanism to facilitate processing of higher image speeds in
behavioral contexts where these speeds of visual motion are
relevant for course stabilization.
@article{chiappe_walking_2010,
abstract = {Changes in behavioral state modify neural activity in many
systems [1{\textendash}5]. In some vertebrates such modulation
has been observed and interpreted in the context of attention
[2] and sensorimotor coordinate transformations [3]. Here we
report state-dependent activity modulations during walking in
a visual-motor pathway of Drosophila. We used two-photon
imaging to monitor intracellular calcium activity in
motion-sensitive lobula plate tangential cells ({LPTCs)} in
head-fixed Drosophila walking on an air-supported ball. Cells
of the horizontal system ({HS){\textemdash}a} subgroup of
{LPTCs{\textemdash}showed} stronger calcium transients in
response to visual motion when flies were walking rather than
resting. The amplified responses were also correlated with
walking speed. Moreover, {HS} neurons showed a relatively
higher gain in response strength at higher temporal
frequencies, and their optimum temporal frequency was shifted
toward higher motion speeds. Walking-dependent modulation of
{HS} neurons in the Drosophila visual system may constitute a
mechanism to facilitate processing of higher image speeds in
behavioral contexts where these speeds of visual motion are
relevant for course stabilization.},
added-at = {2014-01-19T15:14:02.000+0100},
author = {Chiappe, M. Eugenia and Seelig, Johannes D. and Reiser, Michael B. and Jayaraman, Vivek},
bdsk-url-1 = {http://www.sciencedirect.com/science/article/pii/S0960982210008614},
bdsk-url-2 = {http://dx.doi.org/10.1016/j.cub.2010.06.072},
biburl = {https://www.bibsonomy.org/bibtex/27180ccf4a50cf852743389cc4da942de/neurokernel},
doi = {10.1016/j.cub.2010.06.072},
interhash = {bdd9da68383e95e074fa460e59a14ba5},
intrahash = {7180ccf4a50cf852743389cc4da942de},
issn = {0960-9822},
journal = {Current Biology},
keywords = {drosophila vision},
month = aug,
number = 16,
pages = {1470--1475},
timestamp = {2014-01-19T15:14:02.000+0100},
title = {Walking Modulates Speed Sensitivity in {Drosophila} Motion Vision},
url = {http://www.sciencedirect.com/science/article/pii/S0960982210008614},
urldate = {2013-10-17},
volume = 20,
year = 2010
}