Pairing action potentials in synaptically coupled cortical pyramidal
cells induces LTP in a frequency-dependent manner (H. Markram et
al., Science 275 (1997) 213). Using MCell, which simulated the 3D
geometry of the spine and the diffusion and binding of Ca$^2+$,
we show that pairing five EPSPs and back-propagating action potentials
results in a Ca$^2+$ influx into a model dendritic spine that
is largely frequency independent but leads to a frequency-dependent
activation of postsynaptic calmodulin. Furthermore, we show how altering
the availability of calmodulin and the calcium-binding capacity can
alter the efficacy and potency of the frequency-response curve. The
model shows how the cell can regulate its plasticity by buffering
Ca$^2+$ signals.
%0 Journal Article
%1 Fran_2001_9
%A Franks, Kevin M.
%A Bartol, Thomas M.
%A Sejnowski, Terrence J.
%D 2001
%J Neurocomputing
%K Buffering, Calcium, Calmodulin, Frequency-dependence, Long-term potentiation
%P 9--16
%T An MCell model of calcium dynamics and frequency-dependence of calmodulin
activation in dendritic spines
%U http://www.sciencedirect.com/science/article/B6V10-435KK2K-3/2/68fbcdbb174b11111fbf19a8709a455e
%V 38-40
%X Pairing action potentials in synaptically coupled cortical pyramidal
cells induces LTP in a frequency-dependent manner (H. Markram et
al., Science 275 (1997) 213). Using MCell, which simulated the 3D
geometry of the spine and the diffusion and binding of Ca$^2+$,
we show that pairing five EPSPs and back-propagating action potentials
results in a Ca$^2+$ influx into a model dendritic spine that
is largely frequency independent but leads to a frequency-dependent
activation of postsynaptic calmodulin. Furthermore, we show how altering
the availability of calmodulin and the calcium-binding capacity can
alter the efficacy and potency of the frequency-response curve. The
model shows how the cell can regulate its plasticity by buffering
Ca$^2+$ signals.
@article{Fran_2001_9,
abstract = {Pairing action potentials in synaptically coupled cortical pyramidal
cells induces LTP in a frequency-dependent manner (H. Markram et
al., Science 275 (1997) 213). Using MCell, which simulated the 3D
geometry of the spine and the diffusion and binding of {C}a$^{2+}$,
we show that pairing five EPSPs and back-propagating action potentials
results in a {C}a$^{2+}$ influx into a model dendritic spine that
is largely frequency independent but leads to a frequency-dependent
activation of postsynaptic calmodulin. Furthermore, we show how altering
the availability of calmodulin and the calcium-binding capacity can
alter the efficacy and potency of the frequency-response curve. The
model shows how the cell can regulate its plasticity by buffering
{C}a$^{2+}$ signals.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Franks, Kevin M. and Bartol, Thomas M. and Sejnowski, Terrence J.},
biburl = {https://www.bibsonomy.org/bibtex/2719b77b93606ea9c9dafa6445f5c6df0/hake},
description = {The whole bibliography file I use.},
file = {Fran_2001_9.pdf:Fran_2001_9.pdf:PDF},
interhash = {f3e1250eba01dbe6d98007f54f807d1d},
intrahash = {719b77b93606ea9c9dafa6445f5c6df0},
journal = {Neurocomputing},
keywords = {Buffering, Calcium, Calmodulin, Frequency-dependence, Long-term potentiation},
month = {June},
pages = {9--16},
timestamp = {2009-06-03T11:21:12.000+0200},
title = {An MCell model of calcium dynamics and frequency-dependence of calmodulin
activation in dendritic spines},
url = {http://www.sciencedirect.com/science/article/B6V10-435KK2K-3/2/68fbcdbb174b11111fbf19a8709a455e},
volume = {38-40},
year = 2001
}