OBJECTIVE: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.
%0 Journal Article
%1 Wong2004a
%A Wong, Alice M K
%A Chen, Chia-Ling
%A Chen, Carl P C
%A Chou, Shih-Wei
%A Chung, Chia-Ying
%A Chen, Max J L
%D 2004
%J Am J Phys Med Rehabil
%K Botulinum Toxin Type A; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Lower Extremity; Male; Muscle Spasticity; Neuromuscular Agents; Blockade; Phenol; Treatment Outcome
%N 4
%P 284--291
%T Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy.
%V 83
%X OBJECTIVE: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.
@article{Wong2004a,
abstract = {OBJECTIVE: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.},
added-at = {2014-07-19T21:56:27.000+0200},
author = {Wong, Alice M K and Chen, Chia-Ling and Chen, Carl P C and Chou, Shih-Wei and Chung, Chia-Ying and Chen, Max J L},
biburl = {https://www.bibsonomy.org/bibtex/2758857c61cd27475f203e1aa560999ca/ar0berts},
groups = {public},
interhash = {7d52067cc7a57f01f28f27905ec0af55},
intrahash = {758857c61cd27475f203e1aa560999ca},
journal = {Am J Phys Med Rehabil},
keywords = {Botulinum Toxin Type A; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Lower Extremity; Male; Muscle Spasticity; Neuromuscular Agents; Blockade; Phenol; Treatment Outcome},
month = Apr,
number = 4,
pages = {284--291},
pii = {00002060-200404000-00008},
pmid = {15024330},
timestamp = {2014-07-19T21:56:27.000+0200},
title = {Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy.},
username = {ar0berts},
volume = 83,
year = 2004
}