Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80\% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy with FDG-PET imaging and found 47 articles among which there were only 5 studies of 20 patients or more. We were able to conclude that sensitivity and specificity of FDG-PET for Alzheimer's disease are good, but more studies using histopathological diagnosis at autopsy as gold standard are needed in order to evaluate what FDG-PET truly adds to premortem diagnostic accuracy in dementia.
%0 Journal Article
%1 Durand-Martel2010
%A Durand-Martel, Pascali
%A Tremblay, Dominic
%A Brodeur, Catherine
%A Paquet, Nancy
%D 2010
%J Can J Neurol Sci
%K Autopsy methods;Brain diagnosticuse;Humans;Positron-EmissionTomography Factual pathology/radionuclideimaging;FluorodeoxyglucoseF18 methods;Radiopharmaceuticals radionuclideimaging;Databases diagnosticuse;imageriechus statistics/&/numericaldata;Dementia
%N 3
%P 336--342
%T Autopsy as gold standard in FDG-PET studies in dementia.
%V 37
%X Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80\% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy with FDG-PET imaging and found 47 articles among which there were only 5 studies of 20 patients or more. We were able to conclude that sensitivity and specificity of FDG-PET for Alzheimer's disease are good, but more studies using histopathological diagnosis at autopsy as gold standard are needed in order to evaluate what FDG-PET truly adds to premortem diagnostic accuracy in dementia.
@article{Durand-Martel2010,
abstract = {Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80\% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy with FDG-PET imaging and found 47 articles among which there were only 5 studies of 20 patients or more. We were able to conclude that sensitivity and specificity of FDG-PET for Alzheimer's disease are good, but more studies using histopathological diagnosis at autopsy as gold standard are needed in order to evaluate what FDG-PET truly adds to premortem diagnostic accuracy in dementia.},
added-at = {2011-02-17T17:51:42.000+0100},
author = {Durand-Martel, Pascali and Tremblay, Dominic and Brodeur, Catherine and Paquet, Nancy},
biburl = {https://www.bibsonomy.org/bibtex/281cc96264304d538882889e57b6dffdb/edimestre.chus},
institution = {Neurology Service, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.},
interhash = {f39e7059ac071865e49db5b57843e4f1},
intrahash = {81cc96264304d538882889e57b6dffdb},
journal = {Can J Neurol Sci},
keywords = {Autopsy methods;Brain diagnosticuse;Humans;Positron-EmissionTomography Factual pathology/radionuclideimaging;FluorodeoxyglucoseF18 methods;Radiopharmaceuticals radionuclideimaging;Databases diagnosticuse;imageriechus statistics/&/numericaldata;Dementia},
language = {eng},
medline-pst = {ppublish},
month = May,
number = 3,
pages = {336--342},
pmid = {20481267},
timestamp = {2011-03-11T10:08:15.000+0100},
title = {Autopsy as gold standard in FDG-PET studies in dementia.},
volume = 37,
year = 2010
}