An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
Description
AP2gamma regulates basal progenitor fate in a r... [Nat Neurosci. 2009] - PubMed - NCBI
%0 Journal Article
%1 Pinto:2009:Nat-Neurosci:19749747
%A Pinto, L
%A Drechsel, D
%A Schmid, M T
%A Ninkovic, J
%A Irmler, M
%A Brill, M S
%A Restani, L
%A Gianfranceschi, L
%A Cerri, C
%A Weber, S N
%A Tarabykin, V
%A Baer, K
%A Guillemot, F
%A Beckers, J
%A Zecevic, N
%A Dehay, C
%A Caleo, M
%A Schorle, H
%A Götz, M
%D 2009
%J Nat Neurosci
%K Tcfap2c development progenitor stem_cells
%N 10
%P 1229-1237
%R 10.1038/nn.2399
%T AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
%U http://www.ncbi.nlm.nih.gov/pubmed/19749747
%V 12
%X An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
@article{Pinto:2009:Nat-Neurosci:19749747,
abstract = {An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.},
added-at = {2012-09-13T14:49:19.000+0200},
author = {Pinto, L and Drechsel, D and Schmid, M T and Ninkovic, J and Irmler, M and Brill, M S and Restani, L and Gianfranceschi, L and Cerri, C and Weber, S N and Tarabykin, V and Baer, K and Guillemot, F and Beckers, J and Zecevic, N and Dehay, C and Caleo, M and Schorle, H and G{\"o}tz, M},
biburl = {https://www.bibsonomy.org/bibtex/284f316d97b3715c3e1172f86fb4f800e/kilianjay},
description = {AP2gamma regulates basal progenitor fate in a r... [Nat Neurosci. 2009] - PubMed - NCBI},
doi = {10.1038/nn.2399},
interhash = {ba7f2bc6a7080e857aab8348aee7aab9},
intrahash = {84f316d97b3715c3e1172f86fb4f800e},
journal = {Nat Neurosci},
keywords = {Tcfap2c development progenitor stem_cells},
month = oct,
number = 10,
pages = {1229-1237},
pmid = {19749747},
timestamp = {2012-09-13T14:49:19.000+0200},
title = {AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19749747},
volume = 12,
year = 2009
}