%0 Journal Article %1 louicharoen2009positively %A Louicharoen, Chalisa %A Patin, Etienne %A Paul, Richard %A Nuchprayoon, Issarang %A Witoonpanich, Bhee %A Peerapittayamongkol, Chayanon %A Casademont, Isabelle %A Sura, Thanyachai %A Laird, Nan M. %A Singhasivanon, Pratap %A Quintana-Murci, Lluis %A Sakuntabhai, Anavaj %D 2009 %J Science %K G6PD Plasmodium parallel_adaptation %N 5959 %P 1546-1549 %R 10.1126/science.1178849 %T Positively Selected G6PD-Mahidol Mutation Reduces Plasmodium vivax Density in Southeast Asians %U http://www.sciencemag.org/cgi/content/abstract/326/5959/1546 %V 326 %X Glucose-6-phosphate dehydrogenase (G6PD) deficiency--the most common known enzymopathy--is associated with neonatal jaundice and hemolytic anemia usually after exposure to certain infections, foods, or medications. Although G6PD-deficient alleles appear to confer a protective effect against malaria, the link with clinical protection from Plasmodium infection remains unclear. We investigated the effect of a common G6PD deficiency variant in Southeast Asia--the G6PD-Mahidol487A variant--on human survival related to vivax and falciparum malaria. Our results show that strong and recent positive selection has targeted the Mahidol variant over the past 1500 years. We found that the G6PD-Mahidol487A variant reduces vivax, but not falciparum, parasite density in humans, which indicates that Plasmodium vivax has been a driving force behind the strong selective advantage conferred by this mutation.

@article{louicharoen2009positively, abstract = {Glucose-6-phosphate dehydrogenase (G6PD) deficiency--the most common known enzymopathy--is associated with neonatal jaundice and hemolytic anemia usually after exposure to certain infections, foods, or medications. Although G6PD-deficient alleles appear to confer a protective effect against malaria, the link with clinical protection from Plasmodium infection remains unclear. We investigated the effect of a common G6PD deficiency variant in Southeast Asia--the G6PD-Mahidol487A variant--on human survival related to vivax and falciparum malaria. Our results show that strong and recent positive selection has targeted the Mahidol variant over the past 1500 years. We found that the G6PD-Mahidol487A variant reduces vivax, but not falciparum, parasite density in humans, which indicates that Plasmodium vivax has been a driving force behind the strong selective advantage conferred by this mutation. }, added-at = {2009-12-13T00:26:34.000+0100}, author = {Louicharoen, Chalisa and Patin, Etienne and Paul, Richard and Nuchprayoon, Issarang and Witoonpanich, Bhee and Peerapittayamongkol, Chayanon and Casademont, Isabelle and Sura, Thanyachai and Laird, Nan M. and Singhasivanon, Pratap and Quintana-Murci, Lluis and Sakuntabhai, Anavaj}, biburl = {https://www.bibsonomy.org/bibtex/2265ac80b394e98fe2df533aa0948856d/peter.ralph}, description = {Positively Selected G6PD-Mahidol Mutation Reduces Plasmodium vivax Density in Southeast Asians -- Louicharoen et al. 326 (5959): 1546 -- Science}, doi = {10.1126/science.1178849}, eprint = {http://www.sciencemag.org/cgi/reprint/326/5959/1546.pdf}, interhash = {284f5fe6ff630b4f4da041cc8ec9b458}, intrahash = {265ac80b394e98fe2df533aa0948856d}, journal = {Science}, keywords = {G6PD Plasmodium parallel_adaptation}, number = 5959, pages = {1546-1549}, timestamp = {2011-04-27T22:03:56.000+0200}, title = {{Positively Selected G6PD-Mahidol Mutation Reduces Plasmodium vivax Density in Southeast Asians}}, url = {http://www.sciencemag.org/cgi/content/abstract/326/5959/1546}, volume = 326, year = 2009 }