Context: Pithecellobium dulce (PD) is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent.
Aims: To evaluate the acute and sub-acute toxicity of P. dulce stem bark hydroethanolic extract in Wistar rats.
Methods: In the acute test, a single dose of 5 g/kg body weight was administered to Wistar rats afterwards they were observed individually 4 hours post-dosing, and at least once daily for 14 consecutive days. The sub-acute toxicity was evaluated by daily oral administration of 0.5 and 1 g/kg extract, for 28 days. Biochemical and hematological parameters assessment as well as body and organ weights of the rats were carried out.
Results: The limit dose of 5 g/kg did not cause any mortality or signs of acute toxicity on the rats during the experimentation period. In the sub-acute test, uterus-ovary-trompe (UOT) weight decreased dose-dependently: Control group (0.82 ± 0.03 g); Extract 0.5 g/kg (0.57 ± 0.06 g); Extract 1g/kg (0.48 ± 0.01 g) (p ˂ 0.01). Extract lowered urea values in female group treated with 1 g/kg (p < 0.01). Lymphocytes percentage was dose dependently increased in treated male groups: Control group (53.00 ± 0.58%); extract 0.5 g/kg (58.67 ± 0.67%) and extract 1 g/kg (60.67 ± 2.41%).
Conclusions: These findings suggest that PD is relatively safe when administered orally in rats but is slightly atrophic for female reproductive organs.
%0 Journal Article
%1 toudji2017acute
%A Toudji, Gérard A.
%A Dosseh, Kossivi
%A Karou, Simplice D.
%A Adjrah, Yao
%A Anani, Kokou
%A Ameyapoh, Yaovi
%A Simpore, Jacques
%D 2017
%E JPPRes,
%J Journal of Pharmacy & Pharmacognosy Research
%K animal-model medicinal-plants pharmacology toxicology
%N 5
%P 310-319
%T Acute and sub-acute toxicity of Pithecellobium dulce (Roxb.) Benth. stem bark hydroalcoholic extract on Wistar rats
%U http://jppres.com/jppres/pdf/vol5/jppres17.257_5.5.310.pdf
%V 5
%X Context: Pithecellobium dulce (PD) is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent.
Aims: To evaluate the acute and sub-acute toxicity of P. dulce stem bark hydroethanolic extract in Wistar rats.
Methods: In the acute test, a single dose of 5 g/kg body weight was administered to Wistar rats afterwards they were observed individually 4 hours post-dosing, and at least once daily for 14 consecutive days. The sub-acute toxicity was evaluated by daily oral administration of 0.5 and 1 g/kg extract, for 28 days. Biochemical and hematological parameters assessment as well as body and organ weights of the rats were carried out.
Results: The limit dose of 5 g/kg did not cause any mortality or signs of acute toxicity on the rats during the experimentation period. In the sub-acute test, uterus-ovary-trompe (UOT) weight decreased dose-dependently: Control group (0.82 ± 0.03 g); Extract 0.5 g/kg (0.57 ± 0.06 g); Extract 1g/kg (0.48 ± 0.01 g) (p ˂ 0.01). Extract lowered urea values in female group treated with 1 g/kg (p < 0.01). Lymphocytes percentage was dose dependently increased in treated male groups: Control group (53.00 ± 0.58%); extract 0.5 g/kg (58.67 ± 0.67%) and extract 1 g/kg (60.67 ± 2.41%).
Conclusions: These findings suggest that PD is relatively safe when administered orally in rats but is slightly atrophic for female reproductive organs.
@article{toudji2017acute,
abstract = {Context: Pithecellobium dulce (PD) is an annual herbaceous plant commonly used in African traditional medicine as a purgative, antipyretic, anti-ulcer and wound dressing agent.
Aims: To evaluate the acute and sub-acute toxicity of P. dulce stem bark hydroethanolic extract in Wistar rats.
Methods: In the acute test, a single dose of 5 g/kg body weight was administered to Wistar rats afterwards they were observed individually 4 hours post-dosing, and at least once daily for 14 consecutive days. The sub-acute toxicity was evaluated by daily oral administration of 0.5 and 1 g/kg extract, for 28 days. Biochemical and hematological parameters assessment as well as body and organ weights of the rats were carried out.
Results: The limit dose of 5 g/kg did not cause any mortality or signs of acute toxicity on the rats during the experimentation period. In the sub-acute test, uterus-ovary-trompe (UOT) weight decreased dose-dependently: Control group (0.82 ± 0.03 g); Extract 0.5 g/kg (0.57 ± 0.06 g); Extract 1g/kg (0.48 ± 0.01 g) (p ˂ 0.01). Extract lowered urea values in female group treated with 1 g/kg (p < 0.01). Lymphocytes percentage was dose dependently increased in treated male groups: Control group (53.00 ± 0.58%); extract 0.5 g/kg (58.67 ± 0.67%) and extract 1 g/kg (60.67 ± 2.41%).
Conclusions: These findings suggest that PD is relatively safe when administered orally in rats but is slightly atrophic for female reproductive organs.},
added-at = {2017-08-10T00:50:14.000+0200},
author = {Toudji, Gérard A. and Dosseh, Kossivi and Karou, Simplice D. and Adjrah, Yao and Anani, Kokou and Ameyapoh, Yaovi and Simpore, Jacques},
biburl = {https://www.bibsonomy.org/bibtex/28b9cd330b971b448f522a995f906bfd1/jppres},
editor = {JPPRes},
interhash = {d622973d15ad477472e62dcd464156e7},
intrahash = {8b9cd330b971b448f522a995f906bfd1},
issn = {0719-4250},
journal = {Journal of Pharmacy & Pharmacognosy Research},
keywords = {animal-model medicinal-plants pharmacology toxicology},
language = {eng},
month = {sep-oct},
number = 5,
pages = {310-319},
timestamp = {2017-08-10T00:50:14.000+0200},
title = {Acute and sub-acute toxicity of Pithecellobium dulce (Roxb.) Benth. stem bark hydroalcoholic extract on Wistar rats},
url = {http://jppres.com/jppres/pdf/vol5/jppres17.257_5.5.310.pdf},
volume = 5,
year = 2017
}