%0 Journal Article %1 Mittendorf2006 %A Mittendorf, R. %A Dammann, O. %A Lee, K-S. %D 2006 %J J Perinatol %K Basal Ganglia Cerebrovascular Disease; Cerebral Hemorrhage; Palsy; Female; Humans; Infant, Newborn; Magnesium Sulfate; Obstetric Labor, Premature; Pr; Pregnancy; Randomized Controlled Trials; Tocolytic Agents; enatal Exposure Delayed Effects %N 1 %P 57--63 %R 10.1038/sj.jp.7211419 %T Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor. %U http://dx.doi.org/10.1038/sj.jp.7211419 %V 26 %X High-dosage, tocolytic magnesium sulfate (MgSO4) administered to pregnant women during preterm labor can be toxic, and sometimes lethal, for their newborns (Cochrane Database of Systematic Reviews (relative mortality risk 2.82, 95\% confidence interval 1.2-6.6)). Based on the results of the Magnesium and Neurologic Endpoints Trial and the work of many others, a unifying triangular concept is proposed to account for the increased prevalence of brain lesions, with their likely resultant mortality, in neonates and infants exposed to high-dose MgSO4 in the context of preterm labor. We review the evidence that: (1) elevated circulating levels of serum ionized magnesium occurring in mothers, and therefore in their babies, at the time of delivery are associated with subsequent neonatal intraventricular hemorrhage (IVH); (2) neonatal IVH is strongly associated with lenticulostriate vasculopathy (LSV), an unusual mineralizing lesion involving the thalami and basal ganglia of the neonate; and, (3) exposure to 50 g or more of tocolytic MgSO4 during preterm labor is associated with the development of LSV.

@article{Mittendorf2006, abstract = {High-dosage, tocolytic magnesium sulfate (MgSO4) administered to pregnant women during preterm labor can be toxic, and sometimes lethal, for their newborns (Cochrane Database of Systematic Reviews (relative mortality risk 2.82, 95\% confidence interval 1.2-6.6)). Based on the results of the Magnesium and Neurologic Endpoints Trial and the work of many others, a unifying triangular concept is proposed to account for the increased prevalence of brain lesions, with their likely resultant mortality, in neonates and infants exposed to high-dose MgSO4 in the context of preterm labor. We review the evidence that: (1) elevated circulating levels of serum ionized magnesium occurring in mothers, and therefore in their babies, at the time of delivery are associated with subsequent neonatal intraventricular hemorrhage (IVH); (2) neonatal IVH is strongly associated with lenticulostriate vasculopathy (LSV), an unusual mineralizing lesion involving the thalami and basal ganglia of the neonate; and, (3) exposure to 50 g or more of tocolytic MgSO4 during preterm labor is associated with the development of LSV.}, added-at = {2014-07-19T20:48:17.000+0200}, author = {Mittendorf, R. and Dammann, O. and Lee, K-S.}, biburl = {https://www.bibsonomy.org/bibtex/2dc10c11df65610d791a4d4a6380415d1/ar0berts}, doi = {10.1038/sj.jp.7211419}, groups = {public}, interhash = {294ef2e2e1ec67a8c7e470ba7ba5c5c4}, intrahash = {dc10c11df65610d791a4d4a6380415d1}, journal = {J Perinatol}, keywords = {Basal Ganglia Cerebrovascular Disease; Cerebral Hemorrhage; Palsy; Female; Humans; Infant, Newborn; Magnesium Sulfate; Obstetric Labor, Premature; Pr; Pregnancy; Randomized Controlled Trials; Tocolytic Agents; enatal Exposure Delayed Effects}, month = Jan, number = 1, pages = {57--63}, pii = {7211419}, pmid = {16319938}, timestamp = {2014-07-19T20:48:17.000+0200}, title = {Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor.}, url = {http://dx.doi.org/10.1038/sj.jp.7211419}, username = {ar0berts}, volume = 26, year = 2006 }