Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.
%0 Journal Article
%1 Evers:Headache:1998
%A Evers, S.
%A Masur, H.
%A Sörös, P.
%A Brilla, R.
%A Husstedt, I. W.
%C United States
%D 1998
%J Headache
%K Aged;Cross-Over Disease;controlled Headache;Pain, Humans;Misoprostol;Middle Intractable;Chronic Method;Adult Studies;Cluster clinical trial;Double-Blind trial;Male;clinical
%N 8
%P 618-20
%T Prostaglandin analog mechanisms are not effective in refractory chronic cluster headache.
%V 38
%X Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.
@article{Evers:Headache:1998,
abstract = {Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.},
added-at = {2012-04-29T04:45:51.000+0200},
address = {United States},
author = {Evers, S. and Masur, H. and Sörös, P. and Brilla, R. and Husstedt, I. W.},
biburl = {https://www.bibsonomy.org/bibtex/2972b1477838715418d515fde43bbf0aa/asterix},
interhash = {e6c53f81ac5fca8e43ff8255ec18559f},
intrahash = {972b1477838715418d515fde43bbf0aa},
issn = {0017-8748},
journal = {Headache},
keywords = {Aged;Cross-Over Disease;controlled Headache;Pain, Humans;Misoprostol;Middle Intractable;Chronic Method;Adult Studies;Cluster clinical trial;Double-Blind trial;Male;clinical},
month = {9},
number = 8,
organization = {Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.},
pages = {618-20},
publicationstatus = {Published},
pubmedid = {11398306},
sentelink = {file://localhost/Users/peter/Projects/Literature/Sente6/SenteLibrary.sente6lib/Contents/Attachments/Evers/Prostaglandin%20analog%20mechanisms%20are%20not%20effective%20in%20refractory%20chronic%20cluster%20headache.%201998.pdf,Sente,},
timestamp = {2012-04-29T04:45:55.000+0200},
title = {Prostaglandin analog mechanisms are not effective in refractory chronic cluster headache.},
us_nlm_id = {2985091R},
uuid = {F5F41768-5069-44EF-AAED-4F926A1AF48D},
volume = 38,
web_data_source = {PubMed},
year = 1998
}