J. Hume, and R. Harvey. Am. J. Physiol., 261 (3 Pt 1):
C399--C412(September 1991)
Abstract
Nonelectrogenic movement of Cl$^-$ is believed to be responsible
for the active accumulation of intracellular Cl$^-$ in cardiac
muscle. The electro-neutral pathways underlying this nonpassive distribution
of Cl$^-$ are believed to include Cl$^-$-HCO3- exchange,
Na$^+$-dependent cotransport (operating as Na$^+$-Cl$^-$
and Na$^+$-K$^+$-2Cl$^-$ cotransport), and K$^+$-Cl$^-$
cotransport. The electrogenic movement of Cl$^-$ in cardiac muscle
is particularly interesting from a historical perspective. Until
recently, there was some doubt as to whether Cl$^-$ carried any
current in the heart. Early microelectrode experiments indicated
that a Cl$^-$ conductance probably played an important role in
regulating action potential duration and resting membrane potential.
Subsequent voltage-clamp experiments identified a repolarizing, transient
outward current that was believed to be conducted by Cl$^-$,
yet further investigation suggested that this transient outward current
was more likely a K$^+$ current, not a Cl$^-$ current. This
left some doubt as to whether Cl$^-$ played any role in regulating
membrane potential in cardiac muscle. More recent studies, however,
have identified a highly selective Cl$^-$ conductance that is
regulated by intracellular adenosine 3',5'-cyclic monophosphate,
and it appears that this Cl$^-$ current may play an important
role in the regulation of action potential duration and resting membrane
potential.
%0 Journal Article
%1 Hume_1991_C399
%A Hume, J. R.
%A Harvey, R. D.
%D 1991
%J Am. J. Physiol.
%K 1716049 AMP, Animals, Channels, Chloride Chlorides, Cyclic Electrophysiology, Female, Gov't, Heart, Ion Membrane Non-U.S. P.H.S., Potentials, Pregnancy, Proteins, Research Support, U.S.
%N 3 Pt 1
%P C399--C412
%T Chloride conductance pathways in heart.
%U http://ajpcell.physiology.org/cgi/content/abstract/261/3/C399
%V 261
%X Nonelectrogenic movement of Cl$^-$ is believed to be responsible
for the active accumulation of intracellular Cl$^-$ in cardiac
muscle. The electro-neutral pathways underlying this nonpassive distribution
of Cl$^-$ are believed to include Cl$^-$-HCO3- exchange,
Na$^+$-dependent cotransport (operating as Na$^+$-Cl$^-$
and Na$^+$-K$^+$-2Cl$^-$ cotransport), and K$^+$-Cl$^-$
cotransport. The electrogenic movement of Cl$^-$ in cardiac muscle
is particularly interesting from a historical perspective. Until
recently, there was some doubt as to whether Cl$^-$ carried any
current in the heart. Early microelectrode experiments indicated
that a Cl$^-$ conductance probably played an important role in
regulating action potential duration and resting membrane potential.
Subsequent voltage-clamp experiments identified a repolarizing, transient
outward current that was believed to be conducted by Cl$^-$,
yet further investigation suggested that this transient outward current
was more likely a K$^+$ current, not a Cl$^-$ current. This
left some doubt as to whether Cl$^-$ played any role in regulating
membrane potential in cardiac muscle. More recent studies, however,
have identified a highly selective Cl$^-$ conductance that is
regulated by intracellular adenosine 3',5'-cyclic monophosphate,
and it appears that this Cl$^-$ current may play an important
role in the regulation of action potential duration and resting membrane
potential.
@article{Hume_1991_C399,
abstract = {Nonelectrogenic movement of {C}l$^{-}$ is believed to be responsible
for the active accumulation of intracellular {C}l$^{-}$ in cardiac
muscle. The electro-neutral pathways underlying this nonpassive distribution
of {C}l$^{-}$ are believed to include {C}l$^{-}$-{HCO}3- exchange,
{N}a$^{+}$-dependent cotransport (operating as {N}a$^{+}$-{C}l$^{-}$
and {N}a$^{+}$-{K}$^{+}$-2{C}l$^{-}$ cotransport), and {K}$^{+}$-{C}l$^{-}$
cotransport. The electrogenic movement of {C}l$^{-}$ in cardiac muscle
is particularly interesting from a historical perspective. Until
recently, there was some doubt as to whether {C}l$^{-}$ carried any
current in the heart. Early microelectrode experiments indicated
that a {C}l$^{-}$ conductance probably played an important role in
regulating action potential duration and resting membrane potential.
Subsequent voltage-clamp experiments identified a repolarizing, transient
outward current that was believed to be conducted by {C}l$^{-}$,
yet further investigation suggested that this transient outward current
was more likely a {K}$^{+}$ current, not a {C}l$^{-}$ current. This
left some doubt as to whether {C}l$^{-}$ played any role in regulating
membrane potential in cardiac muscle. More recent studies, however,
have identified a highly selective {C}l$^{-}$ conductance that is
regulated by intracellular adenosine 3',5'-cyclic monophosphate,
and it appears that this {C}l$^{-}$ current may play an important
role in the regulation of action potential duration and resting membrane
potential.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Hume, J. R. and Harvey, R. D.},
biburl = {https://www.bibsonomy.org/bibtex/29759f52a74ec98d997185b0437f17bdf/hake},
description = {The whole bibliography file I use.},
file = {Hume_1991_C399.pdf:Hume_1991_C399.pdf:PDF},
interhash = {a459baf3b26c347632654366cb84952b},
intrahash = {9759f52a74ec98d997185b0437f17bdf},
journal = {Am. J. Physiol.},
keywords = {1716049 AMP, Animals, Channels, Chloride Chlorides, Cyclic Electrophysiology, Female, Gov't, Heart, Ion Membrane Non-U.S. P.H.S., Potentials, Pregnancy, Proteins, Research Support, U.S.},
month = Sep,
number = {3 Pt 1},
pages = {C399--C412},
pmid = {1716049},
timestamp = {2009-06-03T11:21:15.000+0200},
title = {Chloride conductance pathways in heart.},
url = {http://ajpcell.physiology.org/cgi/content/abstract/261/3/C399},
volume = 261,
year = 1991
}