%0 Journal Article %1 kim2000group %A Kim, J H %A Beeler, J A %A Vezina, P %D 2000 %J Neuropharmacology %K amphetamine %N 10 %P 1692-1699 %T Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion %U http://www.ncbi.nlm.nih.gov/pubmed/10884551 %V 39 %X Recently, it was reported that blocking metabotropic glutamate receptors (mGluRs) in the rat nucleus accumbens (NAcc) prevents the generation of locomotion by amphetamine (AMPH) in this site. In these studies, the non-selective group I/group II mGluR antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine (R,S)-MCPG was used. The present study used more selective receptor antagonists to examine the specific contribution of group I and group II mGluRs to this effect. When co-injected bilaterally with AMPH into the NAcc, the group II selective mGluR antagonist (2S)-alpha-ethylglutamic acid EGLU; 0.5-5.0 nmole/side dose-dependently blocked the locomotion and rearing produced by AMPH. Equimolar concentrations of the group I selective antagonist (R,S)-1-aminoindan-1,5-dicarboxylic acid AIDA; 0.5-5.0 nmole/side were without effect. As previously reported for (R,S)-MCPG, neither of these receptor antagonists produced locomotor effects when injected alone in these concentrations into the NAcc. These results suggest that group II, but not group I, mGluRs in the rat NAcc contribute importantly to the ability of AMPH to produce locomotor activation.

@article{kim2000group, abstract = {Recently, it was reported that blocking metabotropic glutamate receptors (mGluRs) in the rat nucleus accumbens (NAcc) prevents the generation of locomotion by amphetamine (AMPH) in this site. In these studies, the non-selective group I/group II mGluR antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine [(R,S)-MCPG] was used. The present study used more selective receptor antagonists to examine the specific contribution of group I and group II mGluRs to this effect. When co-injected bilaterally with AMPH into the NAcc, the group II selective mGluR antagonist (2S)-alpha-ethylglutamic acid [EGLU; 0.5-5.0 nmole/side] dose-dependently blocked the locomotion and rearing produced by AMPH. Equimolar concentrations of the group I selective antagonist (R,S)-1-aminoindan-1,5-dicarboxylic acid [AIDA; 0.5-5.0 nmole/side] were without effect. As previously reported for (R,S)-MCPG, neither of these receptor antagonists produced locomotor effects when injected alone in these concentrations into the NAcc. These results suggest that group II, but not group I, mGluRs in the rat NAcc contribute importantly to the ability of AMPH to produce locomotor activation.}, added-at = {2013-07-11T17:43:15.000+0200}, author = {Kim, J H and Beeler, J A and Vezina, P}, biburl = {https://www.bibsonomy.org/bibtex/297a1a910753735a739adf1fef46e8fce/kilianjay}, description = {Group II, but not group I, metabotropic gl... [Neuropharmacology. 2000] - PubMed - NCBI}, interhash = {6ee3950798b7632963d8f203cde7f7ef}, intrahash = {97a1a910753735a739adf1fef46e8fce}, journal = {Neuropharmacology}, keywords = {amphetamine}, month = jul, number = 10, pages = {1692-1699}, pmid = {10884551}, timestamp = {2013-07-11T17:43:16.000+0200}, title = {Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10884551}, volume = 39, year = 2000 }