%0 Journal Article %1 WOS:000328005400053 %A Honorato, Sara Braga %A Mendonca, Jorge Souza %A Boechat, Nubia %A Oliveira, Alcemira Conceicao %A Filho, Josue Mendes %A Ellena, Javier %A Ayala, Alejandro Pedro %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %D 2014 %I PERGAMON-ELSEVIER SCIENCE LTD %J SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY %K Hot Infrared Polymorphism; Thermal X-ray analysis; diffraction; microscopy; powder spectroscopy} stage {Benznidazole; %P 389-394 %R 10.1016/j.saa.2013.08.096 %T Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole %V 118 %X Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed. (C) 2013 Elsevier B.V. All rights reserved.

@article{WOS:000328005400053, abstract = {Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed. (C) 2013 Elsevier B.V. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, author = {Honorato, Sara Braga and Mendonca, Jorge Souza and Boechat, Nubia and Oliveira, Alcemira Conceicao and Filho, Josue Mendes and Ellena, Javier and Ayala, Alejandro Pedro}, biburl = {https://www.bibsonomy.org/bibtex/29e24c05e2b487bfce291cc4add247913/ppgfis_ufc_br}, doi = {10.1016/j.saa.2013.08.096}, interhash = {2dee85f63f9e188336acf58a566de061}, intrahash = {9e24c05e2b487bfce291cc4add247913}, issn = {1386-1425}, journal = {SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY}, keywords = {Hot Infrared Polymorphism; Thermal X-ray analysis; diffraction; microscopy; powder spectroscopy} stage {Benznidazole;}, pages = {389-394}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole}, tppubtype = {article}, volume = 118, year = 2014 }