Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.
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%0 Journal Article
%1 schneider_vim-15_2008
%A Schneider, Ines
%A Keuleyan, Emma
%A Rasshofer, Rudolf
%A Markovska, Rumyana
%A Queenan, Anne Marie
%A Bauernfeind, Adolf
%D 2008
%J Antimicrobial Agents and Chemotherapy
%K Acid Amino Analysis, Bacterial Bulgaria, Catalysis, Data, Germany, Hydrolysis, Isoenzymes, Kinetics, Microbial Molecular Proteins, Pseudomonas Sensitivity Sequence Substitution, Tests, aeruginosa, {DNA} {beta-Lactamases,}
%N 8
%P 2977--2979
%R 10.1128/AAC.00175-08
%T VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany
%U http://www.ncbi.nlm.nih.gov/pubmed/18519714
%V 52
%X Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.
@article{schneider_vim-15_2008,
abstract = {Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new {VIM-2} variants. {VIM-15} had one amino acid substitution {(Tyr218Phe)} which caused a significant increase in hydrolytic efficiency. The substitution {Ser54Leu,} characterizing {VIM-16,} showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Schneider, Ines and Keuleyan, Emma and Rasshofer, Rudolf and Markovska, Rumyana and Queenan, Anne Marie and Bauernfeind, Adolf},
biburl = {https://www.bibsonomy.org/bibtex/25da0b245dec18c7072d94bbf91775a6d/jelias},
doi = {10.1128/AAC.00175-08},
interhash = {2a002b54f61b875279414531ce1319b7},
intrahash = {5da0b245dec18c7072d94bbf91775a6d},
issn = {1098-6596},
journal = {Antimicrobial Agents and Chemotherapy},
keywords = {Acid Amino Analysis, Bacterial Bulgaria, Catalysis, Data, Germany, Hydrolysis, Isoenzymes, Kinetics, Microbial Molecular Proteins, Pseudomonas Sensitivity Sequence Substitution, Tests, aeruginosa, {DNA} {beta-Lactamases,}},
month = aug,
note = {{PMID:} 18519714},
number = 8,
pages = {2977--2979},
timestamp = {2011-03-11T10:06:29.000+0100},
title = {{VIM-15} and {VIM-16,} two new {VIM-2-like} metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18519714},
volume = 52,
year = 2008
}