Connections between perturbations that lie outside of our genome,
that is, epigenetic alternations, and tumorigenesis have become increasingly
apparent. Dynamic chromatin remodeling of the fundamental nucleosomal
structure (covered in this review) or the covalent marks residing
in the histone proteins that make up this structure (covered previously
in part I) underlie many fundamental cellular processes, including
transcriptional regulation and DNA-damage repair. Dysregulation of
these processes has been linked to cancer development. Mechanisms
of chromatin remodeling include dynamic interplay between ATP-dependent
complexes, covalent histone modifications, utilization of histone
variants and DNA methylation. In part II of this series, we focus
on connections between ATP-dependent chromatin-remodeling complexes
and oncogenesis and discuss the potential clinical implications of
chromatin remodeling and cancer.
Laboratory of Chromatin Biology, The Rockefeller University, and
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New
York, NY 10021, USA.
journal
Trends Mol Med
number
9
pages
373-380
volume
13
pmid
17822959
timestamp
2009.04.26
pii
S1471-4914(07)00147-5
file
article:../Chromatin/Chromatin remodeling and cancer%2C Part I%3A
Covalent histone modfications.pdf:pdf
%0 Journal Article
%1 Wang2007a
%A Wang, Gang G.
%A Allis, C. David
%A Chi, Ping
%D 2007
%J Trends Mol Med
%K Adenosine_Triphosphate,_metabolism/physiology Animals Chromatin,_metabolism/physiology Histones,_chemistry/metabolism Humans Models,_Biological Neoplasms,_metabolism/physiopathology Protein_Processing,_Post-Translational
%N 9
%P 373-380
%R 10.1016/j.molmed.2007.07.004
%T Chromatin remodeling and cancer, Part II: ATP-dependent chromatin
remodeling.
%U http://dx.doi.org/10.1016/j.molmed.2007.07.004
%V 13
%X Connections between perturbations that lie outside of our genome,
that is, epigenetic alternations, and tumorigenesis have become increasingly
apparent. Dynamic chromatin remodeling of the fundamental nucleosomal
structure (covered in this review) or the covalent marks residing
in the histone proteins that make up this structure (covered previously
in part I) underlie many fundamental cellular processes, including
transcriptional regulation and DNA-damage repair. Dysregulation of
these processes has been linked to cancer development. Mechanisms
of chromatin remodeling include dynamic interplay between ATP-dependent
complexes, covalent histone modifications, utilization of histone
variants and DNA methylation. In part II of this series, we focus
on connections between ATP-dependent chromatin-remodeling complexes
and oncogenesis and discuss the potential clinical implications of
chromatin remodeling and cancer.
@article{Wang2007a,
abstract = {Connections between perturbations that lie outside of our genome,
that is, epigenetic alternations, and tumorigenesis have become increasingly
apparent. Dynamic chromatin remodeling of the fundamental nucleosomal
structure (covered in this review) or the covalent marks residing
in the histone proteins that make up this structure (covered previously
in part I) underlie many fundamental cellular processes, including
transcriptional regulation and DNA-damage repair. Dysregulation of
these processes has been linked to cancer development. Mechanisms
of chromatin remodeling include dynamic interplay between ATP-dependent
complexes, covalent histone modifications, utilization of histone
variants and DNA methylation. In part II of this series, we focus
on connections between ATP-dependent chromatin-remodeling complexes
and oncogenesis and discuss the potential clinical implications of
chromatin remodeling and cancer.},
added-at = {2010-01-26T20:35:53.000+0100},
author = {Wang, Gang G. and Allis, C. David and Chi, Ping},
biburl = {https://www.bibsonomy.org/bibtex/2a95940a5d20f03c9049fab88982730ed/denilw},
doi = {10.1016/j.molmed.2007.07.004},
file = {article:../Chromatin/Chromatin remodeling and cancer%2C Part I%3A
Covalent histone modfications.pdf:pdf},
institution = {Laboratory of Chromatin Biology, The Rockefeller University, and
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New
York, NY 10021, USA.},
interhash = {4d93a6a9c4645061267bfba2e39eef4b},
intrahash = {a95940a5d20f03c9049fab88982730ed},
journal = {Trends Mol Med},
keywords = {Adenosine_Triphosphate,_metabolism/physiology Animals Chromatin,_metabolism/physiology Histones,_chemistry/metabolism Humans Models,_Biological Neoplasms,_metabolism/physiopathology Protein_Processing,_Post-Translational},
month = Sep,
number = 9,
owner = {denilw},
pages = {373-380},
pii = {S1471-4914(07)00147-5},
pmid = {17822959},
timestamp = {2010-01-26T20:36:04.000+0100},
title = {Chromatin remodeling and cancer, Part II: ATP-dependent chromatin
remodeling.},
url = {http://dx.doi.org/10.1016/j.molmed.2007.07.004},
volume = 13,
year = 2007
}