Background
Influenza virus is one of the major viral respiratory pathogens infecting human beings.Objectives
To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France.Study design
Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1.Results
All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients.Conclusion
These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.
Description
ScienceDirect - Journal of Clinical Virology : Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006–2007 epidemic season in Corsica Island, France
%0 Journal Article
%1 Falchi2009265
%A Falchi, Alessandra
%A Varesi, Laurent
%A Arena, Christophe
%A Leveque, Nicolas
%A Renois, Fanny
%A Blanchon, Thierry
%A Amoros, Jean Pierre
%A Andreoletti, Laurent
%D 2009
%J Journal of Clinical Virology
%K antigenic influenza surveillance
%N 3
%P 265--268
%R DOI: 10.1016/j.jcv.2009.05.004
%T Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France
%U http://www.sciencedirect.com/science/article/B6VJV-4WGHJST-1/2/7463a09a63b3855aa63ec31a304ca789
%V 45
%X Background
Influenza virus is one of the major viral respiratory pathogens infecting human beings.Objectives
To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France.Study design
Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1.Results
All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients.Conclusion
These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.
@article{Falchi2009265,
abstract = {Background
Influenza virus is one of the major viral respiratory pathogens infecting human beings.Objectives
To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France.Study design
Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1.Results
All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients.Conclusion
These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.},
added-at = {2009-08-04T18:25:01.000+0200},
author = {Falchi, Alessandra and Varesi, Laurent and Arena, Christophe and Leveque, Nicolas and Renois, Fanny and Blanchon, Thierry and Amoros, Jean Pierre and Andreoletti, Laurent},
biburl = {https://www.bibsonomy.org/bibtex/2a9b59ec71db0578bb943fa8b257047f7/ebo},
description = {ScienceDirect - Journal of Clinical Virology : Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006–2007 epidemic season in Corsica Island, France},
doi = {DOI: 10.1016/j.jcv.2009.05.004},
interhash = {5152097cd19c33041156bb835660393a},
intrahash = {a9b59ec71db0578bb943fa8b257047f7},
issn = {1386-6532},
journal = {Journal of Clinical Virology},
keywords = {antigenic influenza surveillance},
note = {Special section: Novel 2009 influenza A H1N1 (swine variant)},
number = 3,
pages = {265--268},
timestamp = {2009-08-04T18:25:01.000+0200},
title = {Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France},
url = {http://www.sciencedirect.com/science/article/B6VJV-4WGHJST-1/2/7463a09a63b3855aa63ec31a304ca789},
volume = 45,
year = 2009
}