%0 Journal Article %1 ANDRESKA2023112575 %A Andreska, Thomas %A Lüningschrör, Patrick %A Wolf, Daniel %A McFleder, Rhonda L. %A Ayon-Olivas, Maurilyn %A Rattka, Marta %A Drechsler, Christine %A Perschin, Veronika %A Blum, Robert %A Aufmkolk, Sarah %A Granado, Noelia %A Moratalla, Rosario %A Sauer, Markus %A Monoranu, Camelia %A Volkmann, Jens %A Ip, Chi Wang %A Stigloher, Christian %A Sendtner, Michael %D 2023 %J Cell Reports %K extern myown stigloher_high %N 6 %P 112575 %R https://doi.org/10.1016/j.celrep.2023.112575 %T DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons %U https://www.sciencedirect.com/science/article/pii/S2211124723005867 %V 42 %X Summary Disturbed motor control is a hallmark of Parkinson’s disease (PD). Cortico-striatal synapses play a central role in motor learning and adaption, and brain-derived neurotrophic factor (BDNF) from cortico-striatal afferents modulates their plasticity via TrkB in striatal medium spiny projection neurons (SPNs). We studied the role of dopamine in modulating the sensitivity of direct pathway SPNs (dSPNs) to BDNF in cultures of fluorescence-activated cell sorting (FACS)-enriched D1-expressing SPNs and 6-hydroxydopamine (6-OHDA)-treated rats. DRD1 activation causes enhanced TrkB translocation to the cell surface and increased sensitivity for BDNF. In contrast, dopamine depletion in cultured dSPN neurons, 6-OHDA-treated rats, and postmortem brain of patients with PD reduces BDNF responsiveness and causes formation of intracellular TrkB clusters. These clusters associate with sortilin related VPS10 domain containing receptor 2 (SORCS-2) in multivesicular-like structures, which apparently protects them from lysosomal degradation. Thus, impaired TrkB processing might contribute to disturbed motor function in PD.

@article{ANDRESKA2023112575, abstract = {Summary Disturbed motor control is a hallmark of Parkinson’s disease (PD). Cortico-striatal synapses play a central role in motor learning and adaption, and brain-derived neurotrophic factor (BDNF) from cortico-striatal afferents modulates their plasticity via TrkB in striatal medium spiny projection neurons (SPNs). We studied the role of dopamine in modulating the sensitivity of direct pathway SPNs (dSPNs) to BDNF in cultures of fluorescence-activated cell sorting (FACS)-enriched D1-expressing SPNs and 6-hydroxydopamine (6-OHDA)-treated rats. DRD1 activation causes enhanced TrkB translocation to the cell surface and increased sensitivity for BDNF. In contrast, dopamine depletion in cultured dSPN neurons, 6-OHDA-treated rats, and postmortem brain of patients with PD reduces BDNF responsiveness and causes formation of intracellular TrkB clusters. These clusters associate with sortilin related VPS10 domain containing receptor 2 (SORCS-2) in multivesicular-like structures, which apparently protects them from lysosomal degradation. Thus, impaired TrkB processing might contribute to disturbed motor function in PD.}, added-at = {2023-10-04T13:47:11.000+0200}, author = {Andreska, Thomas and Lüningschrör, Patrick and Wolf, Daniel and McFleder, Rhonda L. and Ayon-Olivas, Maurilyn and Rattka, Marta and Drechsler, Christine and Perschin, Veronika and Blum, Robert and Aufmkolk, Sarah and Granado, Noelia and Moratalla, Rosario and Sauer, Markus and Monoranu, Camelia and Volkmann, Jens and Ip, Chi Wang and Stigloher, Christian and Sendtner, Michael}, biburl = {https://www.bibsonomy.org/bibtex/2db5d946dd8385d07465e8754ffdad61d/zam}, doi = {https://doi.org/10.1016/j.celrep.2023.112575}, interhash = {2ad0be264304fd5621cbcf0fc218506d}, intrahash = {db5d946dd8385d07465e8754ffdad61d}, issn = {2211-1247}, journal = {Cell Reports}, keywords = {extern myown stigloher_high}, number = 6, pages = 112575, timestamp = {2023-10-04T15:26:49.000+0200}, title = {DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons}, url = {https://www.sciencedirect.com/science/article/pii/S2211124723005867}, volume = 42, year = 2023 }