%0 Journal Article %1 noauthororeditor %A El-Tabl, Abdou S. %A Wahed, Moshira M. Abd-El %A Abu-Setta, Mohammed H. H. %D 2018 %J International Journal of Advances in Chemistry (IJAC) %K Base Complexes Cytotoxicity ESR Schiff Synthesis %N 1 %P 17-37 %R 10.5121/ijac.2018.4102 %T METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPY %U http://airccse.com/ijac/papers/4118ijac02.pdf %V 4 %X Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry. Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective treatment.

@article{noauthororeditor, abstract = {Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry. Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective treatment. }, added-at = {2018-03-07T07:43:58.000+0100}, author = {El-Tabl, Abdou S. and Wahed, Moshira M. Abd-El and Abu-Setta, Mohammed H. H.}, biburl = {https://www.bibsonomy.org/bibtex/2b76c19aa360728e24e6a101b6f2888fb/ijac}, doi = {10.5121/ijac.2018.4102}, interhash = {9722698fd5c03081b16f3c979513d0b6}, intrahash = {b76c19aa360728e24e6a101b6f2888fb}, issn = {2455-7862}, journal = {International Journal of Advances in Chemistry (IJAC)}, keywords = {Base Complexes Cytotoxicity ESR Schiff Synthesis}, language = {English}, month = feb, number = 1, pages = {17-37}, timestamp = {2018-03-07T07:43:58.000+0100}, title = {METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPY}, url = {http://airccse.com/ijac/papers/4118ijac02.pdf}, volume = 4, year = 2018 }