Synaptic events at the neuromuscular junction are integer multiples
of a quantum, the postsynaptic response to transmitter released from
one presynaptic vesicle. At central synapses where quanta are small,
it has been suggested they are invariant due to occupation of all
postsynaptic receptors, a concept neglecting inherent fluctuations
in channel behavior. If this did occur, the quantal release model
would not apply there and could not be used to localize sites of
synaptic modification. Monte Carlo simulations of quanta include
transmitter diffusion and interactions with postsynaptic receptors
that are treated probabilistically. These models suggest that when
there are few postsynaptic channels available at a synapse, their
stochastic behavior produces significant intrinsic variance in response
amplitude and kinetics, and saturation does not occur. These results
were confirmed by analysis of inhibitory quanta in embryonic and
adult Mauthner cells involving a small and large number of channels,
respectively. The findings apply to excitatory synapses as well.
%0 Journal Article
%1 Fabe_1992_1494
%A Faber, D. S.
%A Young, W. S.
%A Legendre, P.
%A Korn, H.
%D 1992
%J Science
%K 1279813 Agents, Animals, Carlo Channels, Diffusion, Goldfish, Gov't, Ion Method, Models, Monte Neurological, Neurotransmitter Neurotransmitter, Non-U.S. P.H.S., Processes, Receptors, Research Statistical, Stochastic Support, Synap, Synapses, Transmission, U.S. Zebrafish, tic
%N 5087
%P 1494--1498
%T Intrinsic quantal variability due to stochastic properties of receptor-transmitter
interactions.
%V 258
%X Synaptic events at the neuromuscular junction are integer multiples
of a quantum, the postsynaptic response to transmitter released from
one presynaptic vesicle. At central synapses where quanta are small,
it has been suggested they are invariant due to occupation of all
postsynaptic receptors, a concept neglecting inherent fluctuations
in channel behavior. If this did occur, the quantal release model
would not apply there and could not be used to localize sites of
synaptic modification. Monte Carlo simulations of quanta include
transmitter diffusion and interactions with postsynaptic receptors
that are treated probabilistically. These models suggest that when
there are few postsynaptic channels available at a synapse, their
stochastic behavior produces significant intrinsic variance in response
amplitude and kinetics, and saturation does not occur. These results
were confirmed by analysis of inhibitory quanta in embryonic and
adult Mauthner cells involving a small and large number of channels,
respectively. The findings apply to excitatory synapses as well.
@article{Fabe_1992_1494,
abstract = {Synaptic events at the neuromuscular junction are integer multiples
of a quantum, the postsynaptic response to transmitter released from
one presynaptic vesicle. At central synapses where quanta are small,
it has been suggested they are invariant due to occupation of all
postsynaptic receptors, a concept neglecting inherent fluctuations
in channel behavior. If this did occur, the quantal release model
would not apply there and could not be used to localize sites of
synaptic modification. Monte Carlo simulations of quanta include
transmitter diffusion and interactions with postsynaptic receptors
that are treated probabilistically. These models suggest that when
there are few postsynaptic channels available at a synapse, their
stochastic behavior produces significant intrinsic variance in response
amplitude and kinetics, and saturation does not occur. These results
were confirmed by analysis of inhibitory quanta in embryonic and
adult Mauthner cells involving a small and large number of channels,
respectively. The findings apply to excitatory synapses as well.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Faber, D. S. and Young, W. S. and Legendre, P. and Korn, H.},
biburl = {https://www.bibsonomy.org/bibtex/2b79a85a63fda19657b2257e86ab99604/hake},
description = {The whole bibliography file I use.},
file = {Fabe_1992_1494.pdf:Fabe_1992_1494.pdf:PDF},
interhash = {9642b2d91f4523862f886f79615ebb12},
intrahash = {b79a85a63fda19657b2257e86ab99604},
journal = {Science},
keywords = {1279813 Agents, Animals, Carlo Channels, Diffusion, Goldfish, Gov't, Ion Method, Models, Monte Neurological, Neurotransmitter Neurotransmitter, Non-U.S. P.H.S., Processes, Receptors, Research Statistical, Stochastic Support, Synap, Synapses, Transmission, U.S. Zebrafish, tic},
month = Nov,
number = 5087,
pages = {1494--1498},
pmid = {1279813},
timestamp = {2009-06-03T11:21:11.000+0200},
title = {Intrinsic quantal variability due to stochastic properties of receptor-transmitter
interactions.},
volume = 258,
year = 1992
}