K. Klotz. Naunyn Schmiedebergs Arch Pharmacol, 362 (4-5):
382-91(November 2000)Klotz, K N Research Support, Non-U.S. Gov't Review Germany Naunyn-Schmiedeberg's
archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2000
Nov;362(4-5):382-91..
Abstract
The regulatory actions of adenosine are mediated via four subtypes
of G protein-coupled receptors distinguished as A1, A2A, A2B and
A3 receptors. Their presence on basically every cell makes them an
interesting target for the pharmacological intervention in many pathophysiological
situations. A large number of ligands have been synthesized over
the last two decades and provide agonists and antagonists that are
more or less selective for the known receptor subtypes. In addition,
many radioligands are available in tritiated or radioiodinated form.
The comparative pharmacological characterization of all four human
adenosine receptor subtypes revealed that some of the compounds thought
to be selective from data in other species have unexpected potencies
at human receptors. As a result, compounds that exhibit high affinity
to only one subtype are an exception. Although the selection of ligands
is immense, it is less than satisfying for most subtypes of adenosine
receptors.
Klotz, K N Research Support, Non-U.S. Gov't Review Germany Naunyn-Schmiedeberg's
archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2000
Nov;362(4-5):382-91.
%0 Journal Article
%1 Klotz2000
%A Klotz, K. N.
%D 2000
%J Naunyn Schmiedebergs Arch Pharmacol
%K Animals Assay Humans Ligands P1/analysis/*drug Purinergic Radioligand Relationship Structure-Activity Xanthine/pharmacology effects/physiology Receptor
%N 4-5
%P 382-91
%T Adenosine receptors and their ligands
%U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11111832
%V 362
%X The regulatory actions of adenosine are mediated via four subtypes
of G protein-coupled receptors distinguished as A1, A2A, A2B and
A3 receptors. Their presence on basically every cell makes them an
interesting target for the pharmacological intervention in many pathophysiological
situations. A large number of ligands have been synthesized over
the last two decades and provide agonists and antagonists that are
more or less selective for the known receptor subtypes. In addition,
many radioligands are available in tritiated or radioiodinated form.
The comparative pharmacological characterization of all four human
adenosine receptor subtypes revealed that some of the compounds thought
to be selective from data in other species have unexpected potencies
at human receptors. As a result, compounds that exhibit high affinity
to only one subtype are an exception. Although the selection of ligands
is immense, it is less than satisfying for most subtypes of adenosine
receptors.
@article{Klotz2000,
abstract = {The regulatory actions of adenosine are mediated via four subtypes
of G protein-coupled receptors distinguished as A1, A2A, A2B and
A3 receptors. Their presence on basically every cell makes them an
interesting target for the pharmacological intervention in many pathophysiological
situations. A large number of ligands have been synthesized over
the last two decades and provide agonists and antagonists that are
more or less selective for the known receptor subtypes. In addition,
many radioligands are available in tritiated or radioiodinated form.
The comparative pharmacological characterization of all four human
adenosine receptor subtypes revealed that some of the compounds thought
to be selective from data in other species have unexpected potencies
at human receptors. As a result, compounds that exhibit high affinity
to only one subtype are an exception. Although the selection of ligands
is immense, it is less than satisfying for most subtypes of adenosine
receptors.},
added-at = {2010-12-14T18:12:02.000+0100},
author = {Klotz, K. N.},
biburl = {https://www.bibsonomy.org/bibtex/2c023037212c5f6a7624a94583f74a8a8/pharmawuerz},
endnotereftype = {Journal Article},
interhash = {0e334b4e883e5659d89fed6291d57833},
intrahash = {c023037212c5f6a7624a94583f74a8a8},
issn = {0028-1298 (Print) 0028-1298 (Linking)},
journal = {Naunyn Schmiedebergs Arch Pharmacol},
keywords = {Animals Assay Humans Ligands P1/analysis/*drug Purinergic Radioligand Relationship Structure-Activity Xanthine/pharmacology effects/physiology Receptor},
month = Nov,
note = {Klotz, K N Research Support, Non-U.S. Gov't Review Germany Naunyn-Schmiedeberg's
archives of pharmacology Naunyn Schmiedebergs Arch Pharmacol. 2000
Nov;362(4-5):382-91.},
number = {4-5},
pages = {382-91},
shorttitle = {Adenosine receptors and their ligands},
timestamp = {2010-12-14T18:20:04.000+0100},
title = {Adenosine receptors and their ligands},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11111832},
volume = 362,
year = 2000
}