%0 Journal Article %1 WOS:000253036900045 %A Cavaleanti, B C %A Moura, D J %A Rosa, R M %A Moraes, M O %A Araujo, E C C %A Lima, M A S %A Silveira, E R %A Saffi, J %A Henriques, J A P %A Pessoa, C %A Costa-Lotufo, L V %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %D 2008 %I PERGAMON-ELSEVIER SCIENCE LTD %J FOOD AND CHEMICAL TOXICOLOGY %K assay; comet diterpene; martiusii; micronucleus plant tanshinones; test} {Hyptis %N 1 %P 388-392 %R 10.1016/j.fct.2007.08.009 %T Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line %V 46 %X The genotoxic effect of two tanshinones isolated from roots of Hyptis martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung) cells by the alkaline comet assay and micronucleus test. Tanshinones were incubated with the cells at concentrations of 1, 3, 6 and 12 mu g/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic against V79 cells at all tested concentrations. The data obtained provide support to the view that tanshinones has DNA damaging activity in cultured V79 cells under the conditions of the assays. (C) 2007 Elsevier Ltd. All rights reserved.

@article{WOS:000253036900045, abstract = {The genotoxic effect of two tanshinones isolated from roots of Hyptis martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung) cells by the alkaline comet assay and micronucleus test. Tanshinones were incubated with the cells at concentrations of 1, 3, 6 and 12 mu g/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic against V79 cells at all tested concentrations. The data obtained provide support to the view that tanshinones has DNA damaging activity in cultured V79 cells under the conditions of the assays. (C) 2007 Elsevier Ltd. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, author = {Cavaleanti, B C and Moura, D J and Rosa, R M and Moraes, M O and Araujo, E C C and Lima, M A S and Silveira, E R and Saffi, J and Henriques, J A P and Pessoa, C and Costa-Lotufo, L V}, biburl = {https://www.bibsonomy.org/bibtex/2c74c484d071f809fa2d53713a0972b3d/ppgfis_ufc_br}, doi = {10.1016/j.fct.2007.08.009}, interhash = {b3b904eed4b85aa72841a59214086b14}, intrahash = {c74c484d071f809fa2d53713a0972b3d}, issn = {0278-6915}, journal = {FOOD AND CHEMICAL TOXICOLOGY}, keywords = {assay; comet diterpene; martiusii; micronucleus plant tanshinones; test} {Hyptis}, number = 1, pages = {388-392}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Genotoxic effects of tanshinones from Hyptis martiusii in V79 cell line}, tppubtype = {article}, volume = 46, year = 2008 }