Abstract
The genotoxic effect of two tanshinones isolated from roots of Hyptis
martiussi Benth (Labiatae) was studied using V79 (Chinese hamster lung)
cells by the alkaline comet assay and micronucleus test. Tanshinones
were incubated with the cells at concentrations of 1, 3, 6 and 12 mu
g/mL for 3 h. Tanshinones were shown to be quite strongly genotoxic
against V79 cells at all tested concentrations. The data obtained
provide support to the view that tanshinones has DNA damaging activity
in cultured V79 cells under the conditions of the assays. (C) 2007
Elsevier Ltd. All rights reserved.
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