%0 Journal Article %1 wu2015quercetin %A Wu, W %A Li, R %A Li, X %A He, J %A Jiang, S %A Liu, S %A Yang, J %D 2015 %J Viruses %K influenza quercetin %N 1 %R 10.3390/v8010006 %T Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728566/ %V 8 %X Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, making it a potential target for anti-influenza therapeutics development. Here we found that quercetin inhibited influenza infection with a wide spectrum of strains, including A/Puerto Rico/8/34 (H1N1), A/FM-1/47/1 (H1N1), and A/Aichi/2/68 (H3N2) with half maximal inhibitory concentration (IC50) of 7.756 ± 1.097, 6.225 ± 0.467, and 2.738 ± 1.931 μg/mL, respectively. Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections.

@article{wu2015quercetin, abstract = {Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, making it a potential target for anti-influenza therapeutics development. Here we found that quercetin inhibited influenza infection with a wide spectrum of strains, including A/Puerto Rico/8/34 (H1N1), A/FM-1/47/1 (H1N1), and A/Aichi/2/68 (H3N2) with half maximal inhibitory concentration (IC50) of 7.756 ± 1.097, 6.225 ± 0.467, and 2.738 ± 1.931 μg/mL, respectively. Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections. }, added-at = {2020-08-13T21:20:49.000+0200}, author = {Wu, W and Li, R and Li, X and He, J and Jiang, S and Liu, S and Yang, J}, biburl = {https://www.bibsonomy.org/bibtex/2c7f7226237d0af45622de3fe1854fee3/fordham1}, description = {Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry}, doi = {10.3390/v8010006}, interhash = {40562088594c37e1ea07b3f2ebec20e7}, intrahash = {c7f7226237d0af45622de3fe1854fee3}, journal = {Viruses}, keywords = {influenza quercetin}, month = dec, number = 1, pmid = {26712783}, timestamp = {2020-08-13T21:20:49.000+0200}, title = {Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728566/}, volume = 8, year = 2015 }