Peptoids for Biomimetic Hierarchical Structures
Hierarchical Macromolecular Structures: 60 Years after the Staudinger Nobel Prize II, volume 262 of Advances in Polymer Science, Springer International Publishing, (2013)DOI: 10.1007/12_2013_237
Abstract
Life as we know it is impossible without formation of hierarchical structures. First and foremost, proteins, that is, sequence-specific polypeptides, are nature′s vanguard in this respect. Peptoids and polypeptoids are structural isomers and analogs to peptides and polypeptides. Here, we review the advancements over the last few years on biomimetic hierarchical structures obtained using polypeptoids. Although the inherently more flexible amide bond in peptoids make the stabilization of secondary structure challenging, it also gives us a tool to direct the conformation of the amide bond by design. As will be seen, this is a particularly important feature of peptoids.