It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.
Description
ScienceDirect - Theoretical Population Biology : Can one learn history from the allelic spectrum?
%0 Journal Article
%1 myers2008learn
%A Myers, Simon
%A Fefferman, Charles
%A Patterson, Nick
%D 2008
%J Theoretical Population Biology
%K ill-posed_problems inference nonidentifiability population_history site_frequency_spectrum
%N 3
%P 342--348
%R DOI: 10.1016/j.tpb.2008.01.001
%T Can one learn history from the allelic spectrum?
%U http://www.sciencedirect.com/science/article/B6WXD-4RPTJ5G-1/2/818415053006c8321b24cd82c281da60
%V 73
%X It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.
@article{myers2008learn,
abstract = {It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.},
added-at = {2009-11-05T19:43:47.000+0100},
author = {Myers, Simon and Fefferman, Charles and Patterson, Nick},
biburl = {https://www.bibsonomy.org/bibtex/2c86c41223d7b5d01869ddf4ce39e5939/peter.ralph},
description = {ScienceDirect - Theoretical Population Biology : Can one learn history from the allelic spectrum?},
doi = {DOI: 10.1016/j.tpb.2008.01.001},
interhash = {5fd7eccd6c452972408d9a21bbdddd48},
intrahash = {c86c41223d7b5d01869ddf4ce39e5939},
issn = {0040-5809},
journal = {Theoretical Population Biology},
keywords = {ill-posed_problems inference nonidentifiability population_history site_frequency_spectrum},
number = 3,
pages = {342--348},
timestamp = {2013-01-31T00:26:48.000+0100},
title = {Can one learn history from the allelic spectrum?},
url = {http://www.sciencedirect.com/science/article/B6WXD-4RPTJ5G-1/2/818415053006c8321b24cd82c281da60},
volume = 73,
year = 2008
}