%0 Journal Article %1 Görgens20131539 %A Görgens, André %A Radtke, Stefan %A Möllmann, Michael %A Cross, Michael %A Dürig, Jan %A Horn, Peter A. %A Giebel, Bernd %D 2013 %J Cell Reports %K haematopoiesis %N 5 %P 1539 - 1552 %R http://dx.doi.org/10.1016/j.celrep.2013.04.025 %T Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages %U http://www.sciencedirect.com/science/article/pii/S2211124713002076 %V 3 %X Summary The classical model of hematopoiesis predicts a dichotomous lineage restriction of multipotent hematopoietic progenitors (MPPs) into common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs). However, this idea has been challenged by the identification of lymphoid progenitors retaining partial myeloid potential (e.g., LMPPs), implying that granulocytes can arise within both the classical lymphoid and the myeloid branches. Here, we resolve this issue by using cell-surface \CD133\ expression to discriminate functional progenitor populations. We show that eosinophilic and basophilic granulocytes as well as erythrocytes and megakaryocytes derive from a common erythro-myeloid progenitor (EMP), whereas neutrophilic granulocytes arise independently within a lympho-myeloid branch with long-term progenitor function. These findings challenge the concept of a \CMP\ and restore dichotomy to the classical hematopoietic model.

@article{Görgens20131539, abstract = {Summary The classical model of hematopoiesis predicts a dichotomous lineage restriction of multipotent hematopoietic progenitors (MPPs) into common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs). However, this idea has been challenged by the identification of lymphoid progenitors retaining partial myeloid potential (e.g., LMPPs), implying that granulocytes can arise within both the classical lymphoid and the myeloid branches. Here, we resolve this issue by using cell-surface \{CD133\} expression to discriminate functional progenitor populations. We show that eosinophilic and basophilic granulocytes as well as erythrocytes and megakaryocytes derive from a common erythro-myeloid progenitor (EMP), whereas neutrophilic granulocytes arise independently within a lympho-myeloid branch with long-term progenitor function. These findings challenge the concept of a \{CMP\} and restore dichotomy to the classical hematopoietic model. }, added-at = {2015-03-13T16:22:10.000+0100}, author = {Görgens, André and Radtke, Stefan and Möllmann, Michael and Cross, Michael and Dürig, Jan and Horn, Peter A. and Giebel, Bernd}, biburl = {https://www.bibsonomy.org/bibtex/24f80391ecc8e69f28ad456d7afd97bb2/gwotto}, description = {Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages}, doi = {http://dx.doi.org/10.1016/j.celrep.2013.04.025}, interhash = {2c9d90ee464bf6bed432d536c9d3227d}, intrahash = {4f80391ecc8e69f28ad456d7afd97bb2}, issn = {2211-1247}, journal = {Cell Reports }, keywords = {haematopoiesis}, number = 5, pages = {1539 - 1552}, timestamp = {2015-03-13T16:22:10.000+0100}, title = {Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages }, url = {http://www.sciencedirect.com/science/article/pii/S2211124713002076}, volume = 3, year = 2013 }