Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa
R. Bonomo, and D. Szabo. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, (September 2006)PMID: 16894515.
DOI: 10.1086/504477
Abstract
Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.
%0 Journal Article
%1 bonomo_mechanisms_2006
%A Bonomo, Robert A
%A Szabo, Dora
%D 2006
%J Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
%K Acinetobacter, Aminoglycosides, Bacterial, Cross Drug Humans, Infection, Membrane Multiple, Porins, Proteins, Pseudomonas Quinolones Resistance, Transport aeruginosa, {beta-Lactamases,}
%P S49--56
%R 10.1086/504477
%T Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa
%U http://www.ncbi.nlm.nih.gov/pubmed/16894515
%V 43 Suppl 2
%X Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.
@article{bonomo_mechanisms_2006,
abstract = {Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Bonomo, Robert A and Szabo, Dora},
biburl = {https://www.bibsonomy.org/bibtex/2cb6670f2673b11745135fb92a8035518/jelias},
doi = {10.1086/504477},
interhash = {b5f6ca5c335ea143c660757750674028},
intrahash = {cb6670f2673b11745135fb92a8035518},
issn = {1537-6591},
journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
keywords = {Acinetobacter, Aminoglycosides, Bacterial, Cross Drug Humans, Infection, Membrane Multiple, Porins, Proteins, Pseudomonas Quinolones Resistance, Transport aeruginosa, {beta-Lactamases,}},
month = sep,
note = {{PMID:} 16894515},
pages = {S49--56},
timestamp = {2011-03-11T10:06:15.000+0100},
title = {Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16894515},
volume = {43 Suppl 2},
year = 2006
}