Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in a highly context-dependent manner in many different tissues. These secreted protein ligands signal via single-transmembrane Type I and Type II serine/threonine kinase receptors and intracellular SMAD transcription factors. Deregulation in signaling has been implicated in a broad array of diseases, and implicate the need for intricate fine tuning in cellular signaling responses. One important emerging mechanism by which TGF-β family receptor signaling intensity, duration, specificity and diversity are regulated and/or mediated is through cell surface co-receptors. Here, we provide an overview of the co-receptors that have been identified for TGF-β family members. While some appear to be specific to TGF-β family members, others are shared with other pathways and provide possible ways for signal integration. This review focuses on novel functions of TGF-β family co-receptors, which continue to be discovered.
Description
TGF-β family co-receptor function and signaling. - PubMed - NCBI
%0 Journal Article
%1 Nickel:2018:Acta-Biochim-Biophys-Sin-Shanghai:29293886
%A Nickel, J
%A Ten Dijke, P
%A Mueller, T D
%D 2018
%J Acta Biochim Biophys Sin (Shanghai)
%K myown
%N 1
%P 12-36
%R 10.1093/abbs/gmx126
%T TGF-β family co-receptor function and signaling
%U https://www.ncbi.nlm.nih.gov/pubmed/29293886
%V 50
%X Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in a highly context-dependent manner in many different tissues. These secreted protein ligands signal via single-transmembrane Type I and Type II serine/threonine kinase receptors and intracellular SMAD transcription factors. Deregulation in signaling has been implicated in a broad array of diseases, and implicate the need for intricate fine tuning in cellular signaling responses. One important emerging mechanism by which TGF-β family receptor signaling intensity, duration, specificity and diversity are regulated and/or mediated is through cell surface co-receptors. Here, we provide an overview of the co-receptors that have been identified for TGF-β family members. While some appear to be specific to TGF-β family members, others are shared with other pathways and provide possible ways for signal integration. This review focuses on novel functions of TGF-β family co-receptors, which continue to be discovered.
@article{Nickel:2018:Acta-Biochim-Biophys-Sin-Shanghai:29293886,
abstract = {Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in a highly context-dependent manner in many different tissues. These secreted protein ligands signal via single-transmembrane Type I and Type II serine/threonine kinase receptors and intracellular SMAD transcription factors. Deregulation in signaling has been implicated in a broad array of diseases, and implicate the need for intricate fine tuning in cellular signaling responses. One important emerging mechanism by which TGF-β family receptor signaling intensity, duration, specificity and diversity are regulated and/or mediated is through cell surface co-receptors. Here, we provide an overview of the co-receptors that have been identified for TGF-β family members. While some appear to be specific to TGF-β family members, others are shared with other pathways and provide possible ways for signal integration. This review focuses on novel functions of TGF-β family co-receptors, which continue to be discovered.},
added-at = {2018-05-18T21:11:09.000+0200},
author = {Nickel, J and Ten Dijke, P and Mueller, T D},
biburl = {https://www.bibsonomy.org/bibtex/2ccd82da76979ccc9ba4311550aed6d39/tdmueller},
description = {TGF-β family co-receptor function and signaling. - PubMed - NCBI},
doi = {10.1093/abbs/gmx126},
interhash = {4d46d3b617c3022da14fbc0541adccd5},
intrahash = {ccd82da76979ccc9ba4311550aed6d39},
journal = {Acta Biochim Biophys Sin (Shanghai)},
keywords = {myown},
month = jan,
number = 1,
pages = {12-36},
pmid = {29293886},
timestamp = {2018-05-18T21:11:09.000+0200},
title = {TGF-β family co-receptor function and signaling},
url = {https://www.ncbi.nlm.nih.gov/pubmed/29293886},
volume = 50,
year = 2018
}