%0 Journal Article %1 Eisn_2004_583 %A Eisner, D. A. %A D�az, M. E. %A O'Neill, S. C. %A Trafford, A. W. %D 2004 %J Cell Calcium %K 15110148 Adaptation, Animals, Arrhythmia, Calc, Calcium Calcium, Channel Channel, Channels, Conduction Contraction, Fluid, Gating, Gov't, Heart Heart, Humans, Intracellular Ion Muscle, Myocardial Myocardium, Non-U.S. Physiological, Receptor Release Research Reticulum, Ryanodine Sarcoplasmic Skeletal, Support, System, ium %N 6 %P 583--589 %R 10.1016/j.ceca.2004.01.012 %T Physiological and pathological modulation of ryanodine receptor function in cardiac muscle. %U http://dx.doi.org/10.1016/j.ceca.2004.01.012 %V 35 %X Calcium release from the sarcoplasmic reticulum (SR) in cardiac muscle occurs through a specialised release channel, the ryanodine receptor, RyR, via the process of Ca-induced Ca release (CICR). The open probability of the RyR is increased by elevation of cytoplasmic Ca concentration (Ca$^2+$(i)). However, in addition to Ca, other modulators affect the RyR open probability. Agents which increase the RyR opening during systole produce a transient increase of systolic Ca$^2+$(i) followed by a return to the initial level due to a compensating decrease of SR Ca content. Increasing RyR opening during diastole decreases SR Ca content and thereby decreases systolic Ca$^2+$(i). We therefore conclude that potentiation of RyR opening will, if anything, decrease systolic Ca$^2+$(i). The effects of specific examples of modulators of the RyR, such as phosphorylation, metabolic changes, heart failure and polyunsaturated fatty acids, are discussed.

@article{Eisn_2004_583, abstract = {Calcium release from the sarcoplasmic reticulum (SR) in cardiac muscle occurs through a specialised release channel, the ryanodine receptor, RyR, via the process of Ca-induced Ca release (CICR). The open probability of the RyR is increased by elevation of cytoplasmic Ca concentration ([{C}a$^{2+}$](i)). However, in addition to Ca, other modulators affect the RyR open probability. Agents which increase the RyR opening during systole produce a transient increase of systolic [{C}a$^{2+}$](i) followed by a return to the initial level due to a compensating decrease of SR Ca content. Increasing RyR opening during diastole decreases SR Ca content and thereby decreases systolic [{C}a$^{2+}$](i). We therefore conclude that potentiation of RyR opening will, if anything, decrease systolic [{C}a$^{2+}$](i). The effects of specific examples of modulators of the RyR, such as phosphorylation, metabolic changes, heart failure and polyunsaturated fatty acids, are discussed.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Eisner, D. A. and D�az, M. E. and O'Neill, S. C. and Trafford, A. W.}, biburl = {https://www.bibsonomy.org/bibtex/2d33a4bc5e119605823385573137d2327/hake}, description = {The whole bibliography file I use.}, doi = {10.1016/j.ceca.2004.01.012}, file = {Eisn_2004_583.pdf:Eisn_2004_583.pdf:PDF}, interhash = {bce3e503f638101cce6de9882869072b}, intrahash = {d33a4bc5e119605823385573137d2327}, journal = {Cell Calcium}, key = 271, keywords = {15110148 Adaptation, Animals, Arrhythmia, Calc, Calcium Calcium, Channel Channel, Channels, Conduction Contraction, Fluid, Gating, Gov't, Heart Heart, Humans, Intracellular Ion Muscle, Myocardial Myocardium, Non-U.S. Physiological, Receptor Release Research Reticulum, Ryanodine Sarcoplasmic Skeletal, Support, System, ium}, month = Jun, number = 6, pages = {583--589}, pii = {S014341600400020X}, pmid = {15110148}, timestamp = {2009-06-03T11:21:10.000+0200}, title = {Physiological and pathological modulation of ryanodine receptor function in cardiac muscle.}, url = {http://dx.doi.org/10.1016/j.ceca.2004.01.012}, volume = 35, year = 2004 }