Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.
OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6\%; P < 0.01) and DXR-MCI (-31.0\%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9\% (P < 0.01; Sharp erosion part) to -39.1\% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3\%) and DXR-MCI (-23.3\%) as well as JSD-MCP mean (-17.5\%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.
%0 Journal Article
%1 Bottcher:InvestRadiol:2006
%A Böttcher, Joachim
%A Pfeil, Alexander
%A Rosholm, Anders
%A Sörös, Peter
%A Petrovitch, Alexander
%A Schaefer, Max L.
%A Seidl, Bettina E.
%A Malich, Ansgar
%A Hansch, Andreas
%A Wolf, Gunter
%A Kaiser, Werner A.
%C United States
%D 2006
%J Invest Radiol
%K 80 Aged;Statistics, Demineralization, Enhancement;Aged;Arthritis, Illness Image Index;Adolescent Joint;Bone Models;Aged, Nonparametric;Female;Metacarpophalangeal Pathologic;Male;Radiographic Photon;Middle Progression;Humans;Absorptiometry, Rheumatoid;Software;Linear and gov't;Disease non-u.s. of over;Adult;Severity research support,
%N 1
%P 36-44
%T Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.
%V 41
%X OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6\%; P < 0.01) and DXR-MCI (-31.0\%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9\% (P < 0.01; Sharp erosion part) to -39.1\% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3\%) and DXR-MCI (-23.3\%) as well as JSD-MCP mean (-17.5\%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.
@article{Bottcher:InvestRadiol:2006,
abstract = {OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6\%; P < 0.01) and DXR-MCI (-31.0\%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9\% (P < 0.01; Sharp erosion part) to -39.1\% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3\%) and DXR-MCI (-23.3\%) as well as JSD-MCP mean (-17.5\%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.},
added-at = {2012-04-29T04:45:51.000+0200},
address = {United States},
author = {Böttcher, Joachim and Pfeil, Alexander and Rosholm, Anders and Sörös, Peter and Petrovitch, Alexander and Schaefer, Max L. and Seidl, Bettina E. and Malich, Ansgar and Hansch, Andreas and Wolf, Gunter and Kaiser, Werner A.},
biburl = {https://www.bibsonomy.org/bibtex/2d7f96650a9e782c43f01c0bab6f24b09/asterix},
interhash = {4db11a4e3a0465f2b0005957415f4dd3},
intrahash = {d7f96650a9e782c43f01c0bab6f24b09},
issn = {0020-9996},
journal = {Invest Radiol},
keywords = {80 Aged;Statistics, Demineralization, Enhancement;Aged;Arthritis, Illness Image Index;Adolescent Joint;Bone Models;Aged, Nonparametric;Female;Metacarpophalangeal Pathologic;Male;Radiographic Photon;Middle Progression;Humans;Absorptiometry, Rheumatoid;Software;Linear and gov't;Disease non-u.s. of over;Adult;Severity research support,},
month = {1},
number = 1,
organization = {Institute of Diagnostic and Interventional Radiology; Friedrich-Schiller-University Jena, Germany. joachim.boettcher\@med.uni-jena.de},
pages = {36-44},
pii = {00004424-200601000-00006},
publicationstatus = {Published},
pubmedid = {16355038},
sentelink = {file://localhost/Users/peter/Projects/Literature/Sente6/SenteLibrary.sente6lib/Contents/Attachments/B%C3%B6ttcher/Computerized%20quantification%20of%20joint%20space%20narrowing%20and%20periarticular%20demineralization%20in%20patients.pdf,Sente,},
timestamp = {2012-04-29T04:45:53.000+0200},
title = {Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.},
us_nlm_id = {0045377},
uuid = {996A04E0-9308-4777-A47F-55039B5FFB11},
volume = 41,
web_data_source = {PubMed},
year = 2006
}