Viscoelastic properties of skin samples were measured in three types
of mice (tight skin, Tsk, control and Mov-13), that are known to
differ with regard to content of type I collagen. The experimental
design used uniaxial stretching and measured the creep response and
the complex compliance. The creep response was measured directly.
The complex compliance was determined using a Wiener-Volterra constitutive
model for each sample. The models were calculated from data obtained
by applying a stress input having a pseudo-Gaussian waveform and
measuring the strain response. The storage compliance of Mov-13 and
control skin were similar and were greater than Tsk (p<0.001). The
loss compliance of each group was significantly different (p<0.001)
from each other group; Tsk had the lowest and control had the highest
loss compliance. The phase angle of the Mov-13 and Tsk were similar
and were less than the controls (p<0.001). The creep response was
fit with a linear viscoelastic model. None of the parameters in the
creep model differed between groups. The results indicate that gene-targeted
and mutant animals have soft tissue mechanical phenotypes that differ
in complex ways. Caution should be exercised when using such animals
as models to explore the role of specific constituents on tissue
properties.
%0 Journal Article
%1 DelPrete2004
%A Prete, Z. Del
%A Antoniucci, S.
%A Hoffman, A. H.
%A Grigg, P.
%D 2004
%J Journal of Biomechanics
%K Mov-13 Skin, Tsk, Viscoelasticity,
%N 10
%P 1491--1497
%T Viscoelastic properties of skin in Mov-13 and Tsk mice
%U http://www.sciencedirect.com/science/article/B6T82-4BYBY5Y-2/2/7b7a4bb6b3e6518788bd1e74f911bdb7
%V 37
%X Viscoelastic properties of skin samples were measured in three types
of mice (tight skin, Tsk, control and Mov-13), that are known to
differ with regard to content of type I collagen. The experimental
design used uniaxial stretching and measured the creep response and
the complex compliance. The creep response was measured directly.
The complex compliance was determined using a Wiener-Volterra constitutive
model for each sample. The models were calculated from data obtained
by applying a stress input having a pseudo-Gaussian waveform and
measuring the strain response. The storage compliance of Mov-13 and
control skin were similar and were greater than Tsk (p<0.001). The
loss compliance of each group was significantly different (p<0.001)
from each other group; Tsk had the lowest and control had the highest
loss compliance. The phase angle of the Mov-13 and Tsk were similar
and were less than the controls (p<0.001). The creep response was
fit with a linear viscoelastic model. None of the parameters in the
creep model differed between groups. The results indicate that gene-targeted
and mutant animals have soft tissue mechanical phenotypes that differ
in complex ways. Caution should be exercised when using such animals
as models to explore the role of specific constituents on tissue
properties.
@article{DelPrete2004,
abstract = {Viscoelastic properties of skin samples were measured in three types
of mice (tight skin, Tsk, control and Mov-13), that are known to
differ with regard to content of type I collagen. The experimental
design used uniaxial stretching and measured the creep response and
the complex compliance. The creep response was measured directly.
The complex compliance was determined using a Wiener-Volterra constitutive
model for each sample. The models were calculated from data obtained
by applying a stress input having a pseudo-Gaussian waveform and
measuring the strain response. The storage compliance of Mov-13 and
control skin were similar and were greater than Tsk (p<0.001). The
loss compliance of each group was significantly different (p<0.001)
from each other group; Tsk had the lowest and control had the highest
loss compliance. The phase angle of the Mov-13 and Tsk were similar
and were less than the controls (p<0.001). The creep response was
fit with a linear viscoelastic model. None of the parameters in the
creep model differed between groups. The results indicate that gene-targeted
and mutant animals have soft tissue mechanical phenotypes that differ
in complex ways. Caution should be exercised when using such animals
as models to explore the role of specific constituents on tissue
properties.},
added-at = {2009-08-01T18:41:40.000+0200},
author = {Prete, Z. Del and Antoniucci, S. and Hoffman, A. H. and Grigg, P.},
biburl = {https://www.bibsonomy.org/bibtex/2dca73d83a229188a509b7116a8b94093/jaksonmv},
file = {:D\:\\Users\\Jaksonmv\\Documents\\papers\\DelPrete2004.pdf:PDF},
interhash = {21cc013e20ada4e1f59576938a223436},
intrahash = {dca73d83a229188a509b7116a8b94093},
issn = {0021-9290},
journal = {Journal of Biomechanics},
keywords = {Mov-13 Skin, Tsk, Viscoelasticity,},
month = {October},
number = 10,
owner = {Jaksonmv},
pages = {1491--1497},
timestamp = {2009-08-01T18:41:40.000+0200},
title = {Viscoelastic properties of skin in Mov-13 and Tsk mice},
url = {http://www.sciencedirect.com/science/article/B6T82-4BYBY5Y-2/2/7b7a4bb6b3e6518788bd1e74f911bdb7},
volume = 37,
year = 2004
}