The fundamental principle of cardiac behaviour is described by the
Frank-Starling law relating force of contraction during systole with
end-diastolic volume. While both work and respiration rates increase
linearly with imposed load, the basis of mechano-energetic coupling
in heart muscle has remained a long-standing enigma. Here, we highlight
advances made in understanding of complex cellular and molecular
mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation
with ATP utilization for muscle contraction. Cardiac system bioenergetics
critically depends on an interrelated metabolic infrastructure regulating
mitochondrial respiration and energy fluxes throughout cellular compartments.
The data reviewed indicate the significance of two interrelated systems
regulating mitochondrial respiration and energy fluxes in cells:
(1) the creatine kinase, adenylate kinase and glycolytic pathways
that communicate flux changes generated by cellular ATPases within
structurally organized enzymatic modules and networks; and (2) a
secondary system based on mitochondrial participation in cellular
calcium cycle, which adjusts substrate oxidation and energy-transducing
processes to meet increasing cellular energy demands. By conveying
energetic signals to metabolic sensors, coupled phosphotransfer reactions
provide a high-fidelity regulation of the excitation-contraction
cycle. Such integration of energetics with calcium signalling systems
provides the basis for metabolic pacing', synchronizing the cellular
electrical and mechanical activities with energy supply processes.
%0 Journal Article
%1 Saks_2006_253
%A Saks, Valdur
%A Dzeja, Petras
%A Schlattner, Uwe
%A Vendelin, Marko
%A Terzic, Andre
%A Wallimann, Theo
%D 2006
%J J. Physiol. (Lond)
%K imported
%N 2
%P 253-273
%R 10.1113/jphysiol.2005.101444
%T Cardiac system bioenergetics: metabolic basis of the Frank-Starling
law
%U http://jp.physoc.org/cgi/content/abstract/571/2/253
%V 571
%X The fundamental principle of cardiac behaviour is described by the
Frank-Starling law relating force of contraction during systole with
end-diastolic volume. While both work and respiration rates increase
linearly with imposed load, the basis of mechano-energetic coupling
in heart muscle has remained a long-standing enigma. Here, we highlight
advances made in understanding of complex cellular and molecular
mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation
with ATP utilization for muscle contraction. Cardiac system bioenergetics
critically depends on an interrelated metabolic infrastructure regulating
mitochondrial respiration and energy fluxes throughout cellular compartments.
The data reviewed indicate the significance of two interrelated systems
regulating mitochondrial respiration and energy fluxes in cells:
(1) the creatine kinase, adenylate kinase and glycolytic pathways
that communicate flux changes generated by cellular ATPases within
structurally organized enzymatic modules and networks; and (2) a
secondary system based on mitochondrial participation in cellular
calcium cycle, which adjusts substrate oxidation and energy-transducing
processes to meet increasing cellular energy demands. By conveying
energetic signals to metabolic sensors, coupled phosphotransfer reactions
provide a high-fidelity regulation of the excitation-contraction
cycle. Such integration of energetics with calcium signalling systems
provides the basis for metabolic pacing', synchronizing the cellular
electrical and mechanical activities with energy supply processes.
@article{Saks_2006_253,
abstract = {The fundamental principle of cardiac behaviour is described by the
Frank-Starling law relating force of contraction during systole with
end-diastolic volume. While both work and respiration rates increase
linearly with imposed load, the basis of mechano-energetic coupling
in heart muscle has remained a long-standing enigma. Here, we highlight
advances made in understanding of complex cellular and molecular
mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation
with ATP utilization for muscle contraction. Cardiac system bioenergetics
critically depends on an interrelated metabolic infrastructure regulating
mitochondrial respiration and energy fluxes throughout cellular compartments.
The data reviewed indicate the significance of two interrelated systems
regulating mitochondrial respiration and energy fluxes in cells:
(1) the creatine kinase, adenylate kinase and glycolytic pathways
that communicate flux changes generated by cellular ATPases within
structurally organized enzymatic modules and networks; and (2) a
secondary system based on mitochondrial participation in cellular
calcium cycle, which adjusts substrate oxidation and energy-transducing
processes to meet increasing cellular energy demands. By conveying
energetic signals to metabolic sensors, coupled phosphotransfer reactions
provide a high-fidelity regulation of the excitation-contraction
cycle. Such integration of energetics with calcium signalling systems
provides the basis for metabolic pacing', synchronizing the cellular
electrical and mechanical activities with energy supply processes.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Saks, Valdur and Dzeja, Petras and Schlattner, Uwe and Vendelin, Marko and Terzic, Andre and Wallimann, Theo},
biburl = {https://www.bibsonomy.org/bibtex/2e021d8f05ad5c91b3852e45544a462fb/hake},
description = {The whole bibliography file I use.},
doi = {10.1113/jphysiol.2005.101444},
eprint = {http://jp.physoc.org/cgi/reprint/571/2/253.pdf},
file = {Saks_2006_253.pdf:Saks_2006_253.pdf:PDF},
interhash = {f3f3cc5368fd5593d092e78348fd5926},
intrahash = {e021d8f05ad5c91b3852e45544a462fb},
journal = {J. Physiol. (Lond)},
keywords = {imported},
number = 2,
pages = {253-273},
timestamp = {2009-06-03T11:21:28.000+0200},
title = {{Cardiac system bioenergetics: metabolic basis of the Frank-Starling
law}},
url = {http://jp.physoc.org/cgi/content/abstract/571/2/253},
volume = 571,
year = 2006
}