Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6\% of women and 12.5\% of men.
Description
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 | Science
%0 Journal Article
%1 Bastardeabd4585
%D 2020
%E Arias, et al
%I American Association for the Advancement of Science
%J Science
%K Covid-19
%R 10.1126/science.abd4585
%T Auto-antibodies against type I IFNs in patients with life-threatening COVID-19
%U https://science.sciencemag.org/content/early/2020/09/23/science.abd4585
%X Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6\% of women and 12.5\% of men.
@article{Bastardeabd4585,
abstract = {Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6\% of women and 12.5\% of men.},
added-at = {2020-10-13T10:41:48.000+0200},
biburl = {https://www.bibsonomy.org/bibtex/2e28c76213aaefe6b06d004f3714fe7a2/lkanth},
description = {Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 | Science},
doi = {10.1126/science.abd4585},
editor = {Arias, et al},
elocation-id = {eabd4585},
eprint = {https://science.sciencemag.org/content/early/2020/09/23/science.abd4585.full.pdf},
interhash = {1ae0b3d7e5cfeff8b4cc5ba5b6a3d898},
intrahash = {e28c76213aaefe6b06d004f3714fe7a2},
issn = {0036-8075},
journal = {Science},
keywords = {Covid-19},
publisher = {American Association for the Advancement of Science},
timestamp = {2021-08-19T22:16:33.000+0200},
title = {Auto-antibodies against type I IFNs in patients with life-threatening COVID-19},
url = {https://science.sciencemag.org/content/early/2020/09/23/science.abd4585},
year = 2020
}