%0 Journal Article %1 RN122 %A Munoz, O.M. %A Maya, J.D. %A Ferreira, J. %A Christen, P. %A San Martin, J. %A Lopez-Munoz, R. %A Morello, A. %A Kemmerling, U. %D 2013 %J Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences %K anti-trypanosoma antifeedant, chagas-disease, cruzi, dqcauchile drimenol, drugs, growth isodrimenin, toxicity, %N 5-6 %P 198-202 %T Medicinal Plants of Chile: Evaluation of Their Anti-Trypanosoma Cruzi Activity %U /brokenurl#<Go to ISI>://WOS:000323864600005 %V 68 %X The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively.

@article{RN122, abstract = {The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively.}, added-at = {2019-12-04T03:57:35.000+0100}, author = {Munoz, O.M. and Maya, J.D. and Ferreira, J. and Christen, P. and San Martin, J. and Lopez-Munoz, R. and Morello, A. and Kemmerling, U.}, biburl = {https://www.bibsonomy.org/bibtex/2e5e701aa149bd38cb1ec27580e4062b2/dqcauchile}, interhash = {2e7b563f15f06abdbcb2376923a85f85}, intrahash = {e5e701aa149bd38cb1ec27580e4062b2}, issn = {0939-5075}, journal = {Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences}, keywords = {anti-trypanosoma antifeedant, chagas-disease, cruzi, dqcauchile drimenol, drugs, growth isodrimenin, toxicity,}, number = {5-6}, pages = {198-202}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Medicinal Plants of Chile: Evaluation of Their Anti-Trypanosoma Cruzi Activity}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000323864600005}, volume = 68, year = 2013 }