%0 Journal Article %1 citeulike:322839 %A Bradley, Philip %A Misura, Kira M. %A Baker, David %D 2005 %J Science %K ab-initio, post-defense, predictions, rosetta, structure %N 5742 %P 1868--1871 %R 10.1126/science.1113801 %T Toward High-Resolution de Novo Structure Prediction for Small Proteins %U http://dx.doi.org/10.1126/science.1113801 %V 309 %X The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology. By using a combination of improved low- and high-resolution conformational sampling methods, improved atomically detailed potential functions that capture the jigsaw puzzle-like packing of protein cores, and high-performance computing, high-resolution structure prediction (<1.5 angstroms) can be achieved for small protein domains (<85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.

@article{citeulike:322839, abstract = {The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology. By using a combination of improved low- and high-resolution conformational sampling methods, improved atomically detailed potential functions that capture the jigsaw puzzle-like packing of protein cores, and high-performance computing, high-resolution structure prediction (<1.5 angstroms) can be achieved for small protein domains (<85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.}, added-at = {2009-05-19T18:00:18.000+0200}, author = {Bradley, Philip and Misura, Kira M. and Baker, David}, biburl = {https://www.bibsonomy.org/bibtex/2e87e51262c3c8b0bc556eb0a42efb4ee/earthfare}, citeulike-article-id = {322839}, description = {CiteULike: Everyone's library}, doi = {10.1126/science.1113801}, interhash = {cb63637dbe5e761e02adb98a871780d0}, intrahash = {e87e51262c3c8b0bc556eb0a42efb4ee}, journal = {Science}, keywords = {ab-initio, post-defense, predictions, rosetta, structure}, month = {September}, number = 5742, pages = {1868--1871}, posted-at = {2009-05-19 04:17:00}, priority = {2}, timestamp = {2009-05-19T18:03:27.000+0200}, title = {Toward High-Resolution de Novo Structure Prediction for Small Proteins}, url = {http://dx.doi.org/10.1126/science.1113801}, volume = 309, year = 2005 }