%0 Journal Article %1 BARROSO201881 %A Barroso, Maria %A Goday, Albert %A Ramos, Rafel %A Marín-Ibañez, Alejandro %A Guembe, Maria Jesús %A Rigo, Fernando %A Tormo-Díaz, Maria José %A Moreno-Iribas, Conchi %A Cabré, Joan Josep %A Segura, Antonio %A Baena-Díez, Jose Miguel %A de la Cámara, Agustín Gómez %A Lapetra, José %A Quesada, Miquel %A Medrano, María José %A Berjón, Jesús %A Frontera, Guillem %A Gavrila, Diana %A Barricarte, Aurelio %A Basora, Josep %A García, José María %A García-Lareo, Manel %A Lora-Pablos, David %A Mayoral, Eduardo %A Grau, María %A Marrugat, Jaume %D 2018 %J Preventive Medicine %K grapp-caib %P 81-89 %R https://doi.org/10.1016/j.ypmed.2017.11.013 %T Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality %U https://www.sciencedirect.com/science/article/pii/S0091743517304541 %V 107 %X The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35–79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity Hazard Ratio=2.34 (95% confidence interval: 1.19–4.61) and 5.65 (1.54–20.73), respectively. Overweight and obesity significantly increased the risk of cancer death in women 3.98 (1.53–10.37) and 11.61 (1.93–69.72). Finally, obese men had an increased risk of cancer death and overall mortality 1.62 (1.03–2.54) and 1.34 (1.01–1.76), respectively. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.

@article{BARROSO201881, abstract = {The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35–79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19–4.61) and 5.65 (1.54–20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53–10.37) and 11.61 (1.93–69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03–2.54) and 1.34 (1.01–1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.}, added-at = {2022-05-16T22:01:48.000+0200}, author = {Barroso, Maria and Goday, Albert and Ramos, Rafel and Marín-Ibañez, Alejandro and Guembe, Maria Jesús and Rigo, Fernando and Tormo-Díaz, Maria José and Moreno-Iribas, Conchi and Cabré, Joan Josep and Segura, Antonio and Baena-Díez, Jose Miguel and {de la Cámara}, Agustín Gómez and Lapetra, José and Quesada, Miquel and Medrano, María José and Berjón, Jesús and Frontera, Guillem and Gavrila, Diana and Barricarte, Aurelio and Basora, Josep and García, José María and García-Lareo, Manel and Lora-Pablos, David and Mayoral, Eduardo and Grau, María and Marrugat, Jaume}, biburl = {https://www.bibsonomy.org/bibtex/2e89b5c3b6d6c9a628bfbc7ac71118beb/nachoricci}, description = {Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality - ScienceDirect}, doi = {https://doi.org/10.1016/j.ypmed.2017.11.013}, interhash = {6354efcedba549f3843be8e7aa4c8bdb}, intrahash = {e89b5c3b6d6c9a628bfbc7ac71118beb}, issn = {0091-7435}, journal = {Preventive Medicine}, keywords = {grapp-caib}, pages = {81-89}, timestamp = {2022-05-16T22:01:48.000+0200}, title = {Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality}, url = {https://www.sciencedirect.com/science/article/pii/S0091743517304541}, volume = 107, year = 2018 }