%0 Journal Article %1 pathan_changes_2005 %A Pathan, Nazima %A Williams, E John %A Oragui, E Emanuelle %A Stephens, Alick C %A Levin, Michael %D 2005 %J Critical Care Medicine %K Adolescent, Analysis Biological Child, Female, Humans, Illness Index, Infant, Infections, Interleukin-6, London, Male, Markers, Meningococcal Preschool, Receptors, Septic Severity Shock, Variance, of %N 8 %P 1839--1844 %T Changes in the interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock %U http://www.ncbi.nlm.nih.gov/pubmed/16096463 %V 33 %X OBJECTIVE: Interleukin-6 is strongly associated with disease severity and outcome in meningococcal septicemia. It is known that interleukin-6 exerts many of its effects via the soluble interleukin-6 receptor. By facilitating the activity of interleukin-6, it is likely that alterations in the levels of soluble interleukin-6 receptor in septic shock could affect the severity of disease. We aimed to investigate changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcal septicemia and the relationship with disease severity. DESIGN: Laboratory investigation of interleukin-6 and soluble interleukin-6 receptor levels in children with meningococcal disease. SETTING: University hospital and laboratories. SUBJECTS: Children with severe meningococcal disease requiring intensive care. INTERVENTIONS: Blood samples obtained on admission to the intensive care unit were analyzed for interleukin-6 and soluble interleukin-6 receptor levels. Levels were also serially measured for up to 48 hrs in a subset of patients. MEASUREMENTS AND MAIN RESULTS: Cytokine levels were measured by enzyme-linked immunosorbent assay using mouse monoclonal antihuman antibodies. Acute meningococcemia is associated with a reduction in soluble interleukin-6 receptor levels in proportion to disease severity and is inversely related to interleukin-6 levels. Soluble interleukin-6 receptor returns to levels seen in normal donors following recovery from meningococcal septicemia. CONCLUSIONS: Changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcemia may affect the severity and progression of multiple organ failure. Interventions to modulate this axis may improve outcome from meningococcal septic shock.

@article{pathan_changes_2005, abstract = {{OBJECTIVE:} Interleukin-6 is strongly associated with disease severity and outcome in meningococcal septicemia. It is known that interleukin-6 exerts many of its effects via the soluble interleukin-6 receptor. By facilitating the activity of interleukin-6, it is likely that alterations in the levels of soluble interleukin-6 receptor in septic shock could affect the severity of disease. We aimed to investigate changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcal septicemia and the relationship with disease severity. {DESIGN:} Laboratory investigation of interleukin-6 and soluble interleukin-6 receptor levels in children with meningococcal disease. {SETTING:} University hospital and laboratories. {SUBJECTS:} Children with severe meningococcal disease requiring intensive care. {INTERVENTIONS:} Blood samples obtained on admission to the intensive care unit were analyzed for interleukin-6 and soluble interleukin-6 receptor levels. Levels were also serially measured for up to 48 hrs in a subset of patients. {MEASUREMENTS} {AND} {MAIN} {RESULTS:} Cytokine levels were measured by enzyme-linked immunosorbent assay using mouse monoclonal antihuman antibodies. Acute meningococcemia is associated with a reduction in soluble interleukin-6 receptor levels in proportion to disease severity and is inversely related to interleukin-6 levels. Soluble interleukin-6 receptor returns to levels seen in normal donors following recovery from meningococcal septicemia. {CONCLUSIONS:} Changes in the levels of interleukin-6 and soluble interleukin-6 receptor in acute meningococcemia may affect the severity and progression of multiple organ failure. Interventions to modulate this axis may improve outcome from meningococcal septic shock.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Pathan, Nazima and Williams, E John and Oragui, E Emanuelle and Stephens, Alick C and Levin, Michael}, biburl = {https://www.bibsonomy.org/bibtex/2e89ef750a1517923863c8ec4a1390705/jelias}, interhash = {c87a76c0d997f33825398dfada699e6d}, intrahash = {e89ef750a1517923863c8ec4a1390705}, issn = {0090-3493}, journal = {Critical Care Medicine}, keywords = {Adolescent, Analysis Biological Child, Female, Humans, Illness Index, Infant, Infections, Interleukin-6, London, Male, Markers, Meningococcal Preschool, Receptors, Septic Severity Shock, Variance, of}, month = aug, note = {{PMID:} 16096463}, number = 8, pages = {1839--1844}, timestamp = {2011-03-11T10:05:37.000+0100}, title = {Changes in the interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16096463}, volume = 33, year = 2005 }