The effect of spasticity on cortical somatosensory-evoked potentials: changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection.
OBJECTIVE: To evaluate the changes in cortical somatosensory-evoked potentials (SEPs) after botulinum toxin type A injection to determine what effect spasticity has on cortical SEPs. DESIGN: Intervention study and before-after trial. SETTING: University-affiliated hospital in Korea. PARTICIPANTS: Twelve children with spastic hemiplegic cerebral palsy (CP), 7 children with spastic diplegic CP, and 8 patients with traumatic brain injury. INTERVENTION: All participants had botulinum toxin type A injected into the muscles of the spastic limb. MAIN OUTCOME MEASURES: SEPs were recorded before and 7 days after the botulinum toxin type A injection. Spasticity of the affected spastic limb was also measured. The short latency and amplitude of waves in SEPs were measured. The SEP results were divided into 3 groups: flat (no evoked potential), abnormal (evoked but delayed in latency), and normal (clear waveform with normal latency). RESULTS: The normal response of cortical SEP increased after injection. The SEPs exhibited more frequent improvement in the limbs, with greater improvement of spasticity in grade (>1.0 grade) and in patients of younger age (<3y) after injection (P<.05). CONCLUSION: The observed improvement of cortical SEPs with associated reduction of spasticity that occurred after the botulinum toxin type A injection indicates that spasticity itself can be considered a factor affecting cortical SEPs.
%0 Journal Article
%1 Park2002
%A Park, Eun Sook
%A Park, Chang Il
%A Kim, Deog Young
%A Kim, Yong Rae
%D 2002
%J Arch Phys Med Rehabil
%K Adolescent; Adult; Age Factors; Botulinum Toxin Type A; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Hemiplegia; Humans; Infant; Injections, Intramuscular; Magnetic Resonance Imaging; Male; Muscle Spasticity; Neuromuscular Agents; Reaction Time; Severity of Illness Index; Treatment Outcome
%N 11
%P 1592--1596
%T The effect of spasticity on cortical somatosensory-evoked potentials: changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection.
%V 83
%X OBJECTIVE: To evaluate the changes in cortical somatosensory-evoked potentials (SEPs) after botulinum toxin type A injection to determine what effect spasticity has on cortical SEPs. DESIGN: Intervention study and before-after trial. SETTING: University-affiliated hospital in Korea. PARTICIPANTS: Twelve children with spastic hemiplegic cerebral palsy (CP), 7 children with spastic diplegic CP, and 8 patients with traumatic brain injury. INTERVENTION: All participants had botulinum toxin type A injected into the muscles of the spastic limb. MAIN OUTCOME MEASURES: SEPs were recorded before and 7 days after the botulinum toxin type A injection. Spasticity of the affected spastic limb was also measured. The short latency and amplitude of waves in SEPs were measured. The SEP results were divided into 3 groups: flat (no evoked potential), abnormal (evoked but delayed in latency), and normal (clear waveform with normal latency). RESULTS: The normal response of cortical SEP increased after injection. The SEPs exhibited more frequent improvement in the limbs, with greater improvement of spasticity in grade (>1.0 grade) and in patients of younger age (<3y) after injection (P<.05). CONCLUSION: The observed improvement of cortical SEPs with associated reduction of spasticity that occurred after the botulinum toxin type A injection indicates that spasticity itself can be considered a factor affecting cortical SEPs.
@article{Park2002,
abstract = {OBJECTIVE: To evaluate the changes in cortical somatosensory-evoked potentials (SEPs) after botulinum toxin type A injection to determine what effect spasticity has on cortical SEPs. DESIGN: Intervention study and before-after trial. SETTING: University-affiliated hospital in Korea. PARTICIPANTS: Twelve children with spastic hemiplegic cerebral palsy (CP), 7 children with spastic diplegic CP, and 8 patients with traumatic brain injury. INTERVENTION: All participants had botulinum toxin type A injected into the muscles of the spastic limb. MAIN OUTCOME MEASURES: SEPs were recorded before and 7 days after the botulinum toxin type A injection. Spasticity of the affected spastic limb was also measured. The short latency and amplitude of waves in SEPs were measured. The SEP results were divided into 3 groups: flat (no evoked potential), abnormal (evoked but delayed in latency), and normal (clear waveform with normal latency). RESULTS: The normal response of cortical SEP increased after injection. The SEPs exhibited more frequent improvement in the limbs, with greater improvement of spasticity in grade (>1.0 grade) and in patients of younger age (<3y) after injection (P<.05). CONCLUSION: The observed improvement of cortical SEPs with associated reduction of spasticity that occurred after the botulinum toxin type A injection indicates that spasticity itself can be considered a factor affecting cortical SEPs.},
added-at = {2014-07-19T20:59:15.000+0200},
author = {Park, Eun Sook and Park, Chang Il and Kim, Deog Young and Kim, Yong Rae},
biburl = {https://www.bibsonomy.org/bibtex/2eec339ff4bd043a629fb97b08d7929cf/ar0berts},
groups = {public},
interhash = {42a739a039c96357c28fe6c2684a51f1},
intrahash = {eec339ff4bd043a629fb97b08d7929cf},
journal = {Arch Phys Med Rehabil},
keywords = {Adolescent; Adult; Age Factors; Botulinum Toxin Type A; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Hemiplegia; Humans; Infant; Injections, Intramuscular; Magnetic Resonance Imaging; Male; Muscle Spasticity; Neuromuscular Agents; Reaction Time; Severity of Illness Index; Treatment Outcome},
month = Nov,
number = 11,
pages = {1592--1596},
pii = {S0003999302002575},
pmid = {12422331},
timestamp = {2014-07-19T20:59:15.000+0200},
title = {The effect of spasticity on cortical somatosensory-evoked potentials: changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection.},
username = {ar0berts},
volume = 83,
year = 2002
}