%0 Journal Article %1 enriquez_nalidixic_2009 %A Enríquez, Rocío %A Abad, Raquel %A Salcedo, Celia %A Vázquez, Julio A %D 2009 %J Antimicrobial Agents and Chemotherapy %K Acid, Agents, Bacterial, Ciprofloxacin, Drug Humans, Infections, Meningococcal Microbial Nalidixic Neisseria Resistance, Sensitivity Spain Tests, meningitidis, {Anti-Bacterial} %N 2 %P 796--797 %R 10.1128/AAC.00531-08 %T Nalidixic acid disk for laboratory detection of ciprofloxacin resistance in Neisseria meningitidis %U http://www.ncbi.nlm.nih.gov/pubmed/19015355 %V 53 %X Recently the CLSI recommended a disk diffusion method and breakpoints for meningococci which include breakpoints derived for nalidixic acid which serve as surrogate markers for gyrase A mutations associated with diminished fluoroquinolone susceptibility. This study presents the application of this methodology to a panel of 57 meningococcal strains isolated in Spain that include all levels of susceptibility to ciprofloxacin. In conclusion, the most useful method to predict isolates with gyrA mutations that decrease the activity of fluoroquinolones is the use of 30-microg nalidixic acid disks.

@article{enriquez_nalidixic_2009, abstract = {Recently the {CLSI} recommended a disk diffusion method and breakpoints for meningococci which include breakpoints derived for nalidixic acid which serve as surrogate markers for gyrase A mutations associated with diminished fluoroquinolone susceptibility. This study presents the application of this methodology to a panel of 57 meningococcal strains isolated in Spain that include all levels of susceptibility to ciprofloxacin. In conclusion, the most useful method to predict isolates with {gyrA} mutations that decrease the activity of fluoroquinolones is the use of 30-microg nalidixic acid disks.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Enríquez, Rocío and Abad, Raquel and Salcedo, Celia and Vázquez, Julio A}, biburl = {https://www.bibsonomy.org/bibtex/24ac2d8015124483e9cf2fa037fc2379f/jelias}, doi = {10.1128/AAC.00531-08}, interhash = {2f07ba16328aac2c6c9c56582f9e7561}, intrahash = {4ac2d8015124483e9cf2fa037fc2379f}, issn = {1098-6596}, journal = {Antimicrobial Agents and Chemotherapy}, keywords = {Acid, Agents, Bacterial, Ciprofloxacin, Drug Humans, Infections, Meningococcal Microbial Nalidixic Neisseria Resistance, Sensitivity Spain Tests, meningitidis, {Anti-Bacterial}}, month = feb, note = {{PMID:} 19015355}, number = 2, pages = {796--797}, timestamp = {2011-03-11T10:06:28.000+0100}, title = {Nalidixic acid disk for laboratory detection of ciprofloxacin resistance in Neisseria meningitidis}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19015355}, volume = 53, year = 2009 }