%0 Journal Article %1 pelizzoni2020necrotizing %A Pelizzoni, L. %A Lazzari, I. %A Pinto, D. %A Calogero, P. %D 2020 %J Journal of Oncology Research and Therapy %K Carcinoma Cisplatin Gemcitabine Necrotizing nodosa-like pattern polyarteritis vasculitis with %N 1 %P 2 %T Necrotizing Vasculitis with Polyarteritis Nodosa-Like Pattern in a Patient with Urothelial Carcinoma Treated with Gemcitabine %U https://www.gavinpublishers.com/assets/articles_pdf/1582262944article_pdf1876267428.pdf %V 5 %X This manuscript reports a case of necrotizing vasculitis of the lower limbs in a 73-years-old man with a metastatic urothelial carcinoma after second cycle of chemotherapy with gemcitabine and cisplatin. The exact mechanism by which gemcitabine determinates the development of vasculitis in still unknow and does not appear to be related to the number of doses administrated. As soon as the diagnosis of vascular ischemia was made, therapy with gemcitabine and cisplatin was promptly discontinued. The patient’s lower limb was initially erroneously attributed to the prothrombotic effect of gemcitabine, and therefore treatment with anticoagulants and prostaglandin analogues did no prevent the amputation of the left leg. The steroid therapy, introduced after the histological diagnosis of vasculitis of small and medium-sized cutaneous vessels, made it possible to limit the ischemic damage to the contralateral limb. In conclusion, gemcitabine-induced necrotizing vasculitis is a rare adverse event, whose early recognition is essential to immediately establish steroid therapy to limit induced toxicity damage.

@article{pelizzoni2020necrotizing, abstract = {This manuscript reports a case of necrotizing vasculitis of the lower limbs in a 73-years-old man with a metastatic urothelial carcinoma after second cycle of chemotherapy with gemcitabine and cisplatin. The exact mechanism by which gemcitabine determinates the development of vasculitis in still unknow and does not appear to be related to the number of doses administrated. As soon as the diagnosis of vascular ischemia was made, therapy with gemcitabine and cisplatin was promptly discontinued. The patient’s lower limb was initially erroneously attributed to the prothrombotic effect of gemcitabine, and therefore treatment with anticoagulants and prostaglandin analogues did no prevent the amputation of the left leg. The steroid therapy, introduced after the histological diagnosis of vasculitis of small and medium-sized cutaneous vessels, made it possible to limit the ischemic damage to the contralateral limb. In conclusion, gemcitabine-induced necrotizing vasculitis is a rare adverse event, whose early recognition is essential to immediately establish steroid therapy to limit induced toxicity damage.}, added-at = {2020-02-25T13:15:39.000+0100}, author = {Pelizzoni, L. and Lazzari, I. and Pinto, D. and Calogero, P.}, biburl = {https://www.bibsonomy.org/bibtex/2f14e156b375b9f5de333d1f35bae690a/alyssacarter}, interhash = {f31dcc4558a585da229a107822a253d2}, intrahash = {f14e156b375b9f5de333d1f35bae690a}, issn = {2574-710X}, journal = {Journal of Oncology Research and Therapy}, keywords = {Carcinoma Cisplatin Gemcitabine Necrotizing nodosa-like pattern polyarteritis vasculitis with}, language = {English}, month = {February}, number = 1, pages = 2, timestamp = {2021-10-09T12:46:09.000+0200}, title = {Necrotizing Vasculitis with Polyarteritis Nodosa-Like Pattern in a Patient with Urothelial Carcinoma Treated with Gemcitabine}, url = {https://www.gavinpublishers.com/assets/articles_pdf/1582262944article_pdf1876267428.pdf}, volume = 5, year = 2020 }