%0 Journal Article %1 achtman_microevolution_1997 %A Achtman, M %D 1997 %J Gene %K Alleles, Bacterial Disease Evolution, Genetic Genetic, Humans, Infections, Membrane Meningococcal Neisseria Outbreaks, Outer Porins, Proteins, Recombination, Serotyping Variation, meningitidis, %N 1 %P 135--40 %T Microevolution and epidemic spread of serogroup A Neisseria meningitidis--a review %U http://www.ncbi.nlm.nih.gov/pubmed/9224883 %V 192 %X An extensive and representative strain collection of serogroup A Neisseria meningitidis was established. These bacteria were obtained from different endemic and epidemic/pandemic sources and include strains from diseased patients and healthy carriers. The genetic relationships of the bacteria were defined by multi-locus enzyme electrophoresis and sequence polymorphisms of genetically variable antigens have been analyzed in closely-related groupings. The results are interpreted as reflecting a balance of recombination events, which disrupt clonal relationships, and sequential bottlenecks, which purify the bacterial population of genetic variants during epidemic spread.

@article{achtman_microevolution_1997, abstract = {An extensive and representative strain collection of serogroup A Neisseria meningitidis was established. These bacteria were obtained from different endemic and epidemic/pandemic sources and include strains from diseased patients and healthy carriers. The genetic relationships of the bacteria were defined by multi-locus enzyme electrophoresis and sequence polymorphisms of genetically variable antigens have been analyzed in closely-related groupings. The results are interpreted as reflecting a balance of recombination events, which disrupt clonal relationships, and sequential bottlenecks, which purify the bacterial population of genetic variants during epidemic spread.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Achtman, M}, biburl = {https://www.bibsonomy.org/bibtex/2f1530c4dfd2d2433f64520d08dd92e6f/jelias}, interhash = {e081e301b0445d139e2b075f98961350}, intrahash = {f1530c4dfd2d2433f64520d08dd92e6f}, issn = {0378-1119}, journal = {Gene}, keywords = {Alleles, Bacterial Disease Evolution, Genetic Genetic, Humans, Infections, Membrane Meningococcal Neisseria Outbreaks, Outer Porins, Proteins, Recombination, Serotyping Variation, meningitidis,}, month = jun, note = {{PMID:} 9224883}, number = 1, pages = {135--40}, timestamp = {2011-03-11T10:06:37.000+0100}, title = {Microevolution and epidemic spread of serogroup A Neisseria meningitidis--a review}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9224883}, volume = 192, year = 1997 }