%0 Journal Article %1 Skup_2008_2404 %A Skupin, Alexander %A Kettenmann, Helmut %A Winkler, Ulrike %A Wartenberg, Maria %A Sauer, Heinrich %A Tovey, Stephen C %A Taylor, Colin W %A Falcke, Martin %D 2008 %J Biophys. J. %K imported %N 6 %P 2404--2411 %R 10.1529/biophysj.107.119495 %T How does intracellular Ca$^2+$ oscillate: by chance or by the clock? %U http://dx.doi.org/10.1529/biophysj.107.119495 %V 94 %X Ca$^2+$ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca$^2+$ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca$^2+$ using Ca$^2+$ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca$^2+$ oscillations with small standard deviation of ISIs.

@article{Skup_2008_2404, abstract = {{C}a$^{2+}$ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that {C}a$^{2+}$ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free {C}a$^{2+}$ using {C}a$^{2+}$ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular {C}a$^{2+}$ oscillations with small standard deviation of ISIs.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Skupin, Alexander and Kettenmann, Helmut and Winkler, Ulrike and Wartenberg, Maria and Sauer, Heinrich and Tovey, Stephen C and Taylor, Colin W and Falcke, Martin}, biburl = {https://www.bibsonomy.org/bibtex/2f20af5a0db10bae1d1152565a9ce4f90/hake}, description = {The whole bibliography file I use.}, doi = {10.1529/biophysj.107.119495}, file = {Skup_2008_2404.pdf:Skup_2008_2404.pdf:PDF;Skup_2008_2404.pdf:Skup_2008_2404.pdf:PDF}, institution = {Department of Theoretical Physics, Hahn Meitner Institut, Berlin, Germany.}, interhash = {6929e193b39e587e74c6ac1be641a9d0}, intrahash = {f20af5a0db10bae1d1152565a9ce4f90}, journal = {Biophys. J.}, keywords = {imported}, month = Mar, number = 6, pages = {2404--2411}, pii = {biophysj.107.119495}, pmid = {18065468}, timestamp = {2009-06-03T11:21:31.000+0200}, title = {How does intracellular {C}a$^{2+}$ oscillate: by chance or by the clock?}, url = {http://dx.doi.org/10.1529/biophysj.107.119495}, volume = 94, year = 2008 }