We present Neighbor-Net, a distance based method for constructing phylogenetic networks that is based on the Neighbor-Joining (NJ) algorithm of Saitou and Nei. Neighbor-Net provides a snapshot of the data that can guide more detailed analysis. Unlike split decomposition, Neighbor-Net scales well and can quickly produce detailed and informative networks for several hundred taxa. We illustrate the method by reanalyzing three published data sets: a collection of 110 highly recombinant Salmonella multi-locus sequence typing sequences, the 135 Äfrican Eve" human mitochondrial sequences published by Vigilant et al., and a collection of 12 Archeal chaperonin sequences demonstrating strong evidence for gene conversion. Neighbor-Net is available as part of the SplitsTree4 software package.
%0 Journal Article
%1 Bryant04
%A Bryant, David
%A Moulton, Vincent
%C McGill Centre for Bioinformatics, Montreal, Quebec, Canada. bryant\char64mcb.mcgill.ca
%D 2004
%J Mol Biol Evol
%K *Algorithms; *Models, *Phylogeny; Analysis; Animals; Archaeal/genetics; Bacterial Chaperonins/genetics; Cluster Computer DNA, Evolution, Genes, Genetic; Humans; Mitochondrial/genetics; Models, Molecular; Proteins/genetics; Salmonella/genetics; Simulation; Software Theoretical; from:davidjamesbryant
%N 2
%P 255--265
%R 10.1093/molbev/msh018
%T Neighbor-net: an agglomerative method for the construction of phylogenetic networks.
%V 21
%X We present Neighbor-Net, a distance based method for constructing phylogenetic networks that is based on the Neighbor-Joining (NJ) algorithm of Saitou and Nei. Neighbor-Net provides a snapshot of the data that can guide more detailed analysis. Unlike split decomposition, Neighbor-Net scales well and can quickly produce detailed and informative networks for several hundred taxa. We illustrate the method by reanalyzing three published data sets: a collection of 110 highly recombinant Salmonella multi-locus sequence typing sequences, the 135 Äfrican Eve" human mitochondrial sequences published by Vigilant et al., and a collection of 12 Archeal chaperonin sequences demonstrating strong evidence for gene conversion. Neighbor-Net is available as part of the SplitsTree4 software package.
@article{Bryant04,
abstract = {We present Neighbor-Net, a distance based method for constructing phylogenetic networks that is based on the Neighbor-Joining (NJ) algorithm of Saitou and Nei. Neighbor-Net provides a snapshot of the data that can guide more detailed analysis. Unlike split decomposition, Neighbor-Net scales well and can quickly produce detailed and informative networks for several hundred taxa. We illustrate the method by reanalyzing three published data sets: a collection of 110 highly recombinant Salmonella multi-locus sequence typing sequences, the 135 "African Eve" human mitochondrial sequences published by Vigilant et al., and a collection of 12 Archeal chaperonin sequences demonstrating strong evidence for gene conversion. Neighbor-Net is available as part of the SplitsTree4 software package.},
added-at = {2009-01-28T01:17:14.000+0100},
address = {McGill Centre for Bioinformatics, Montreal, Quebec, Canada. bryant{\char64}mcb.mcgill.ca},
au = {Bryant, D and Moulton, V},
author = {Bryant, David and Moulton, Vincent},
biburl = {https://www.bibsonomy.org/bibtex/2f5a3c160033a1d92ce2b82d5096044a7/compevol},
crdt = {2003/12/09 05:00},
da = {20040303},
date-added = {2009-01-28 12:07:05 +1300},
date-modified = {2009-01-28 13:04:38 +1300},
dcom = {20041109},
dep = {20031205},
doi = {10.1093/molbev/msh018},
edat = {2003/12/09 05:00},
interhash = {f4fb24695f81c94be507393fb8b5ee89},
intrahash = {f5a3c160033a1d92ce2b82d5096044a7},
issn = {0737-4038 (Print)},
jid = {8501455},
journal = {Mol Biol Evol},
jt = {Molecular biology and evolution},
keywords = {*Algorithms; *Models, *Phylogeny; Analysis; Animals; Archaeal/genetics; Bacterial Chaperonins/genetics; Cluster Computer DNA, Evolution, Genes, Genetic; Humans; Mitochondrial/genetics; Models, Molecular; Proteins/genetics; Salmonella/genetics; Simulation; Software Theoretical; from:davidjamesbryant},
language = {eng},
lr = {20061115},
mhda = {2004/11/13 09:00},
number = 2,
own = {NLM},
pages = {255--265},
phst = {2003/12/05 {$[$}aheadofprint{$]$}},
pii = {msh018},
pl = {United States},
pmid = {14660700},
pst = {ppublish},
pt = {Journal Article; Research Support, Non-U.S. Gov't},
rn = {0 (Bacterial Proteins); 0 (Chaperonins); 0 (DNA, Mitochondrial)},
sb = {IM},
so = {Mol Biol Evol. 2004 Feb;21(2):255-65. Epub 2003 Dec 5.},
stat = {MEDLINE},
timestamp = {2009-01-28T01:53:33.000+0100},
title = {Neighbor-net: an agglomerative method for the construction of phylogenetic networks.},
volume = 21,
year = 2004
}