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Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites

. International Journal on Bioinformatics & Biosciences (IJBB), Volume 2 (Number 3): 21-29 (September 2012)
DOI: 10.5121/ijbb.2012.2303

Abstract

HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell. Raltegravir and Elvitegravir are two important drugs against integrase.

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