Context: Pavetta crassipes (K. Schum) is used in ethnomedicine for the management of various ailments and food without scientific report of its toxicity profile.
Aims: To evaluate the toxicological effects of Pavetta crassipes leaves in rodents.
Methods: The leaves of Pavetta crassipes were collected from the suburbs of Abuja, Nigeria, dried and powdered using an electric mill. Hot aqueous extraction was done using 250 g of the powdered leaf in 1000 mL distilled water. Lethal dose 50 (LD50) determination was done in mice (intraperitoneally) and rats (orally), twenty-eight-day toxicity testing in rats at doses of 400, 800 and 1600 mg/kg was also done using the aqueous extract. Biochemical, hematological and histological effects were evaluated using standard procedures.
Results: The aqueous leaf extract of Pavetta crassipes (AE) appears safe as the LD50 for intraperitoneal route in mice and oral route in rats was greater than 5000 mg/kg. The results of the 28-day repeated exposure test produced no mortality or adverse effects on the body weights and organ/body weight ratio of rats. Histological changes occurred in the kidneys at 800 and 1600 mg/kg. There was a significant (p<0.01) reduction in AST, ALT, ALP and urea. Lymphocyte (%) and platelet count increased (p<0.01) but neutrophil (%) reduced (p<0.01).
Conclusions: The LD50 of AE was greater than 5000 mg/kg but prolonged use at high doses may produce some adverse effects.
%0 Journal Article
%1 bariweni2018toxicological
%A Bariweni, Moses W.
%A Yibala, Oboma I.
%A Ozolua, Raymond I.
%D 2018
%E JPPRes,
%J Journal of Pharmacy & Pharmacognosy Research
%K LD50 biochemical hematological histology kidney
%N 1
%P 1-16
%T Toxicological studies on the aqueous leaf extract of Pavetta crassipes (K. Schum) in rodents
%U http://jppres.com/jppres/pdf/vol6/jppres17.225_6.1.1.pdf
%V 6
%X Context: Pavetta crassipes (K. Schum) is used in ethnomedicine for the management of various ailments and food without scientific report of its toxicity profile.
Aims: To evaluate the toxicological effects of Pavetta crassipes leaves in rodents.
Methods: The leaves of Pavetta crassipes were collected from the suburbs of Abuja, Nigeria, dried and powdered using an electric mill. Hot aqueous extraction was done using 250 g of the powdered leaf in 1000 mL distilled water. Lethal dose 50 (LD50) determination was done in mice (intraperitoneally) and rats (orally), twenty-eight-day toxicity testing in rats at doses of 400, 800 and 1600 mg/kg was also done using the aqueous extract. Biochemical, hematological and histological effects were evaluated using standard procedures.
Results: The aqueous leaf extract of Pavetta crassipes (AE) appears safe as the LD50 for intraperitoneal route in mice and oral route in rats was greater than 5000 mg/kg. The results of the 28-day repeated exposure test produced no mortality or adverse effects on the body weights and organ/body weight ratio of rats. Histological changes occurred in the kidneys at 800 and 1600 mg/kg. There was a significant (p<0.01) reduction in AST, ALT, ALP and urea. Lymphocyte (%) and platelet count increased (p<0.01) but neutrophil (%) reduced (p<0.01).
Conclusions: The LD50 of AE was greater than 5000 mg/kg but prolonged use at high doses may produce some adverse effects.
@article{bariweni2018toxicological,
abstract = {Context: Pavetta crassipes (K. Schum) is used in ethnomedicine for the management of various ailments and food without scientific report of its toxicity profile.
Aims: To evaluate the toxicological effects of Pavetta crassipes leaves in rodents.
Methods: The leaves of Pavetta crassipes were collected from the suburbs of Abuja, Nigeria, dried and powdered using an electric mill. Hot aqueous extraction was done using 250 g of the powdered leaf in 1000 mL distilled water. Lethal dose 50 (LD50) determination was done in mice (intraperitoneally) and rats (orally), twenty-eight-day toxicity testing in rats at doses of 400, 800 and 1600 mg/kg was also done using the aqueous extract. Biochemical, hematological and histological effects were evaluated using standard procedures.
Results: The aqueous leaf extract of Pavetta crassipes (AE) appears safe as the LD50 for intraperitoneal route in mice and oral route in rats was greater than 5000 mg/kg. The results of the 28-day repeated exposure test produced no mortality or adverse effects on the body weights and organ/body weight ratio of rats. Histological changes occurred in the kidneys at 800 and 1600 mg/kg. There was a significant (p<0.01) reduction in AST, ALT, ALP and urea. Lymphocyte (%) and platelet count increased (p<0.01) but neutrophil (%) reduced (p<0.01).
Conclusions: The LD50 of AE was greater than 5000 mg/kg but prolonged use at high doses may produce some adverse effects.},
added-at = {2018-07-02T09:10:25.000+0200},
author = {Bariweni, Moses W. and Yibala, Oboma I. and Ozolua, Raymond I.},
biburl = {https://www.bibsonomy.org/bibtex/2f783e7778a92385a9734845017a181cb/jppres},
editor = {JPPRes},
interhash = {de4ac4393e28ee058d426c218b0ea5d2},
intrahash = {f783e7778a92385a9734845017a181cb},
issn = {0719-4250},
journal = {Journal of Pharmacy & Pharmacognosy Research},
keywords = {LD50 biochemical hematological histology kidney},
language = {English},
month = {Jan-Feb},
number = 1,
pages = {1-16},
timestamp = {2018-07-02T09:10:25.000+0200},
title = {Toxicological studies on the aqueous leaf extract of Pavetta crassipes (K. Schum) in rodents},
url = {http://jppres.com/jppres/pdf/vol6/jppres17.225_6.1.1.pdf},
volume = 6,
year = 2018
}